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Ointment for treating condyloma acuminatum and preparation method thereof

A technology of condyloma acuminata and ointment, which is applied in the field of medicine, can solve the problems of high cost and complex formula, and achieve the effects of low cost, simple preparation process and reduced economic consumption

Active Publication Date: 2012-11-07
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] A number of Chinese patents have disclosed genital wart topical medicines with javanica javanica oil as an active ingredient, such as CN94103993.5, CN94114957.9, CN94116770.4, CN01142382.X, CN200610001690.8, CN200710062606.8, CN200810084906.0, CN01009012 .9, CN200710025746.8, etc., but these medicines are all mixed with javanica javanica oil and various traditional Chinese medicines or western medicines to achieve the purpose of treating condyloma acuminatum, the formula is complicated and the cost is high

Method used

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  • Ointment for treating condyloma acuminatum and preparation method thereof
  • Ointment for treating condyloma acuminatum and preparation method thereof
  • Ointment for treating condyloma acuminatum and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Optimization of the preparation process of Brucea javanica oil ointment of the present invention

[0024] The formula adopted consists of the following:

[0025] Brucea javanica oil 5 grams;

[0026] Carbopol 0.3 g;

[0027] Soy lecithin 5 grams;

[0028] Glycerin 5 grams;

[0029] Add distilled water to 50 grams;

[0030] The triethanolamine of the amount that adjusts PH to 5~7.

[0031] There are usually three methods of preparation of ointment: grinding and method, fusion method and emulsification method. According to the properties of the main drug javanica javanica oil and the water-based matrix carbopol, this experiment adopts the emulsification method, and according to the equipment conditions of the laboratory, the emulsification method is prepared by three different technological approaches (the specific approaches are as follows) of the emulsifiable cream. Appearance, particle size, and spreadability have been preliminarily investigated, an...

Embodiment 2

[0048] Example 2 Optimization of the formulation of Brucea javanica oil ointment of the present invention

[0049] 1 Single factor investigation of formulation optimization experiment of Brucea javanica ointment

[0050] 1.1 Selection of ointment base.

[0051] In the past, javanica javanica oil ointment used oily base glyceryl monostearate as the ointment excipient base, but glyceryl monostearate contains oleate, and the main component of the main drug javanica javanica oil is oleic acid, so The existence of glyceryl monostearate can bring interference that can't be eliminated in the mensuration of oleic acid content in the ointment, so the present invention selects Carbopol to be the matrix of Brucea javanica oil ointment, to eliminate in the mensuration of oleic acid content. influences. After inspection, the finished ointment made of Carbopol base has a good appearance and no greasy feeling when applied to the skin, which meets the requirements for ointment prep...

Embodiment 3

[0082] Embodiment 3 The efficacy verification data of the present invention are as follows

[0083] The clinical curative effect of the unilateral ointment of javanica javanica oil in the treatment of external condyloma acuminatum was observed, and at the same time, laser treatment of condyloma acuminata and the formula of the first example of "an external drug for treating condyloma acuminatum" of Chinese invention patent ZL200610010902.9 Conduct a comparative test. Take 180 patients who were positive in acetowhite test and HPV in laboratory examination, and were diagnosed with condyloma acuminata. The youngest of the patients was 16 years old and the oldest was 60 years old. Among them, 122 cases were 21 to 30 years old, accounting for 68%. They were randomly divided into an observation group, a control group and a control group with 60 cases in each group.

[0084] The formula of Brucea javanica oil ointment used in the observation group was 5.0 grams of Brucea javanica ...

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Abstract

The invention belongs to the field of a medicine, relating to ointment for treating condyloma acuminatum, which contains the following components by mass: 3-40 parts of brucea javanica oil, 0.1-10 parts of aqueous matrix, 3-40 parts of emulsifier and 10-93.9 parts of water. The ointment disclosed by the invention is a new, non-toxic and harmless prescribed pure traditional Chinese medicine preparation which is free from untoward effects. The pharmacology and the clinical practice confirm that the ointment has the effects of removing putrid tissues and regenerating tissues, and promoting the necrotic tissues to liquefy, decompose and fall off, so that the condyloma acuminatum can be treated as soon as possible, the patients can avoid the surgical pain, other equipments are not needed, and the economic consumption of the patients is reduced as well. The ointment is safer, more effective and convenient to use. Simultaneously, the treatment effect of the ointment is identical to that of the current brucea javanica oil compound preparation by optimizing the prescription and the preparation technology, and the cost is lower, and the preparation technology is more convenient.

Description

technical field [0001] The invention belongs to the field of medicine, relates to an ointment for treating condyloma acuminata, and also relates to a preparation method thereof. Background technique [0002] Condyloma acuminata, also known as condyloma acuminata, genital warts (genital warts), and venereal warts. In recent years, due to the continuous expansion of the extension of sexually transmitted diseases, this disease is recognized as a sexually transmitted disease, and it is also one of the most common sexually transmitted diseases in modern society. [0003] Condyloma acuminatum is one of the most important venereal diseases in our country. In some areas, the incidence accounts for 20% to 31% of all venereal disease patients, ranking second or third. It is more common in the south of my country than in the north, and the age of occurrence is between 16 and 35 years old. Condyloma acuminatum is very contagious and has a high incidence rate. It is second only to nong...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K47/32A61K9/06A61P31/20A61P15/00
Inventor 姚崇舜江永南黄辉球
Owner 惠州市九惠药业有限公司
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