Ointment for treating condyloma acuminatum and preparation method thereof
A technology of condyloma acuminata and ointment, which is applied in the field of medicine, can solve the problems of high cost and complex formula, and achieve the effects of low cost, simple preparation process and reduced economic consumption
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Embodiment 1
[0023] Example 1 Optimization of the preparation process of Brucea javanica oil ointment of the present invention
[0024] The formula adopted consists of the following:
[0025] Brucea javanica oil 5 grams;
[0026] Carbopol 0.3 g;
[0027] Soy lecithin 5 grams;
[0028] Glycerin 5 grams;
[0029] Add distilled water to 50 grams;
[0030] The triethanolamine of the amount that adjusts PH to 5~7.
[0031] There are usually three methods of preparation of ointment: grinding and method, fusion method and emulsification method. According to the properties of the main drug javanica javanica oil and the water-based matrix carbopol, this experiment adopts the emulsification method, and according to the equipment conditions of the laboratory, the emulsification method is prepared by three different technological approaches (the specific approaches are as follows) of the emulsifiable cream. Appearance, particle size, and spreadability have been preliminarily investigated, an...
Embodiment 2
[0048] Example 2 Optimization of the formulation of Brucea javanica oil ointment of the present invention
[0049] 1 Single factor investigation of formulation optimization experiment of Brucea javanica ointment
[0050] 1.1 Selection of ointment base.
[0051] In the past, javanica javanica oil ointment used oily base glyceryl monostearate as the ointment excipient base, but glyceryl monostearate contains oleate, and the main component of the main drug javanica javanica oil is oleic acid, so The existence of glyceryl monostearate can bring interference that can't be eliminated in the mensuration of oleic acid content in the ointment, so the present invention selects Carbopol to be the matrix of Brucea javanica oil ointment, to eliminate in the mensuration of oleic acid content. influences. After inspection, the finished ointment made of Carbopol base has a good appearance and no greasy feeling when applied to the skin, which meets the requirements for ointment prep...
Embodiment 3
[0082] Embodiment 3 The efficacy verification data of the present invention are as follows
[0083] The clinical curative effect of the unilateral ointment of javanica javanica oil in the treatment of external condyloma acuminatum was observed, and at the same time, laser treatment of condyloma acuminata and the formula of the first example of "an external drug for treating condyloma acuminatum" of Chinese invention patent ZL200610010902.9 Conduct a comparative test. Take 180 patients who were positive in acetowhite test and HPV in laboratory examination, and were diagnosed with condyloma acuminata. The youngest of the patients was 16 years old and the oldest was 60 years old. Among them, 122 cases were 21 to 30 years old, accounting for 68%. They were randomly divided into an observation group, a control group and a control group with 60 cases in each group.
[0084] The formula of Brucea javanica oil ointment used in the observation group was 5.0 grams of Brucea javanica ...
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