Microchip and particulate analyzing device
A technology of microchips and tapered parts, applied in the field of microchips and particle analysis devices, can solve problems such as weakening of analysis accuracy, increase of detection signal changes, dispersion of supply positions of particles, etc., and achieve the effect of easy manufacturing
Active Publication Date: 2012-11-14
SONY CORP
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Problems solved by technology
[0010] Therefore, a microchip having a three-pronged channel according to the related art has a problem that, when, for example, a microparticle-containing solution as a sample liquid flows through the channel and is subjected to optical analysis, the microparticles in the vertical direction (depth direction) of the channel supply locations will be dispersed
Therefore, there is a problem that the flow velocity of the microparticles differs depending on the supply position of the microparticles, the variation of the detection signal increases, and the analysis accuracy deteriorates
Method used
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[0056] Preferred embodiments for implementing the present invention will be described below with reference to the accompanying drawings. Note that the embodiments described below are typical exemplary embodiments of the present invention, and the present invention should not be narrowly understood because of these embodiments. This instruction will be provided in the following order.
[0057] 1. According to the fluid velocity vector field in the channel structure of the related art
[0058] 2. Microchip according to the first embodiment of the invention
[0059] 3. Alternative example of the channel structure of the microchip according to the first embodiment
[0060] 4. Microchip according to the second embodiment of the invention
[0061] 5. Alternative example of the channel structure of the microchip according to the second embodiment
[0062] 6. Microchip according to the third embodiment of the invention
[0063] 7. Alternative example of the channel structure of t...
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Abstract
A microchip is provided and the microchip includes a first introduction channel, second introduction channels arranged to sandwich the first introduction channel and merged with the first introduction channel from both sides, and a merge channel connected to the first introduction channel and the second introduction channels, where fluids fed from the first and the second introduction channels are merged and flow, wherein the merge channel has a tapered portion formed so that a channel width in a sandwiching direction along which the first introduction channel is sandwiched by the second introduction channels gradually increases along a fluid feeding direction.
Description
technical field [0001] The present invention relates to a microchip and particle analysis device. More specifically, the present invention relates to a microchip or the like for optically, electrically or magnetically analyzing the properties of particles, such as cells or beads, in a channel. Background technique [0002] Microchips have been developed in recent years in which regions and / or channels for performing chemical and biological analyzes are provided by applying microfabrication techniques used in the semiconductor industry. These microchips are beginning to be used in electrochemical detectors in liquid chromatography, small electrochemical sensors in medical care settings, and more. [0003] Analysis systems using such microchips are called micro-TAS (miniature total analysis system), lab-on-a-chip, biochip, etc., as a method that can improve the speed, efficiency and integration of chemical and biological analysis or reduce the analysis device The size of the...
Claims
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IPC IPC(8): G01N35/08C12M1/00G01N15/14G01N37/00
CPCG01N2015/1413G01N15/1404B01L3/502776G01N15/1056G01N15/1484G01N35/08B01L3/502707B01L2200/10B01L2200/12B01L2300/0867B01L2300/0887G01N1/28
Inventor 伊藤达巳秋山昭次角田正也山崎刚
Owner SONY CORP