Hydrophobic therapueutic agent and solid emulsifier coating for drug coated balloon

A technology of hydrophobic therapeutic agent and emulsifier, which is applied in the direction of coating, catheter, etc., and can solve the problems of short inflation time and short time

Inactive Publication Date: 2012-11-21
ABBOTT CARDIOVASCULAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of the short inflation time required, the time required for drug or coating transfer is therefore short, and therefore there is a challenge specific to drug delivery via drug-coated (or drug-eluting) balloons—drug elution Challenges not presented by stents, drug-eluting stents remain in the patient's vasculature once implanted

Method used

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  • Hydrophobic therapueutic agent and solid emulsifier coating for drug coated balloon
  • Hydrophobic therapueutic agent and solid emulsifier coating for drug coated balloon
  • Hydrophobic therapueutic agent and solid emulsifier coating for drug coated balloon

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Embodiment Construction

[0031] Reference will now be made in detail to inventive embodiments of the disclosed subject matter, some examples of which are illustrated in the accompanying drawings. The disclosed subject matter will be described in conjunction with a detailed description of the devices. The specific embodiments described herein are offered by way of illustration of the disclosed subject matter, and not by way of limitation.

[0032] It should be noted that the term "an" entity or "an" entity refers to one or more of that entity. For example, a protein refers to one or more proteins or at least one protein. Accordingly, the terms "a", "an", "one or more" and "at least one" are used interchangeably herein. The terms "comprising", "including" and "having" are also used interchangeably. Furthermore, the terms "amount" and "level" are also interchangeable and can be used to describe a concentration or a specific amount. Furthermore, the term "selected from" refers to one or more members o...

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Abstract

The disclosed subject matter is directed to a coated medical device such as a balloon or stent and methods of manufacturing the device, where the device has a working length disposed between a distal end and a proximal end thereof; and a coating applied to at least a length of the body. The coating includes a hydrophobic therapeutic agent having a water solubility less than about 15.0 [mu]g / ml and an emulsifier that is a solid at ambient temperature.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 12 / 636,246, filed December 11, 2009, the contents of which are hereby incorporated by reference in their entirety. field of invention [0003] The disclosed subject matter relates to the delivery of insoluble drugs from insertable medical devices. More specifically, the disclosed subject matter relates to medical devices including balloons having a coating of a therapeutic agent with low water solubility and a low drug to emulsifier ratio and an emulsifier. Background of the invention [0004] Atherosclerosis is a syndrome affecting the blood vessels of the arteries. Atherosclerosis is a chronic inflammatory reaction in the arterial wall that is largely due to the accumulation of lipids, macrophages, foam cells, and plaque formation in the arterial wall. Atherosclerosis is commonly referred to as arteriosclerosis, but the pathophysiology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61L29/16
CPCA61L2300/802A61L2300/416A61L29/085A61L2300/606A61L29/143A61L29/16
Inventor S.佩斯蒂J.J.斯坦库斯
Owner ABBOTT CARDIOVASCULAR
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