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Application of neostigmine hyoscyamine in preparation of medicine for treating acute cerebral ischemic injury

A technology of acute cerebral ischemia and scopolamine, which can be used in drug combinations, cardiovascular system diseases, active ingredients of heterocyclic compounds, etc., can solve problems such as applications that have not been reported, and achieve the effect of improving neurological function

Inactive Publication Date: 2012-12-26
高尔医药科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about the application of neoscopolamine in the preparation of medicines for protecting acute cerebral ischemic injury

Method used

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  • Application of neostigmine hyoscyamine in preparation of medicine for treating acute cerebral ischemic injury
  • Application of neostigmine hyoscyamine in preparation of medicine for treating acute cerebral ischemic injury
  • Application of neostigmine hyoscyamine in preparation of medicine for treating acute cerebral ischemic injury

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Experimental program
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Effect test

Embodiment

[0021] 1. Purpose of the test: To observe the protective effect of different doses of neoscopolamine on acute cerebral ischemic injury induced by MCAO in rats through this test, and to determine the time-effect relationship of the drug.

[0022] 2. Test drug: Neostigmine is derived from neostigmine and anisodamine according to the ratio of 1:500. Administered by intraperitoneal injection. Administration volume: 5 ml / kg, administered immediately after successful modeling.

[0023] 3. Experimental animals: SD rats, male, weighing 250-300g, purchased from Shanghai Slack Animal Technology Company.

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Abstract

The invention relates to application of neostigmine hyoscyamine in preparation of a medicine for treating an acute cerebral ischemic injury, wherein the neostigmine hyoscyamine means a combined medicine of the neostigmine and the hyoscyamine. The invention has the following advantages: the application reveals that the neostigmine hyoscyamine has the remarkable functions of protecting the acute cerebral ischemic injury and improving the neurological functions of the acute cerebral ischemic injury, so that a new application field is provided for the neostigmine hyoscyamine; and meanwhile, a new way for treating the acute cerebral ischemic injury is provided.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of neoscopolamine in the preparation of medicines for protecting acute cerebral ischemic injury. Background technique [0002] The incidence of hypertension is high, as high as 18% in Chinese adults. At present, there are about 160 million hypertensive patients in my country. Stroke is the most important complication of hypertension, and the incidence of stroke in Chinese hypertensive patients is much higher than that of hypertensive patients in European and American countries. Once a stroke occurs, the consequences are serious, and the patient is either dead or disabled. There are 15 million new strokes every year in the world, of which 5 million die and 5 million are permanently disabled. Although the study of cerebral ischemic injury in recent years has made great progress in the molecular mechanism of cells, there is no effective treatment method except for the use ...

Claims

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Application Information

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IPC IPC(8): A61K31/46A61P9/10A61P25/00A61K31/27
Inventor 苏定冯刘爱军吴波林莉莉
Owner 高尔医药科技(上海)有限公司
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