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Florfenicol compound composition and preparation method thereof

A florfenicol and compound technology, which is applied in the field of florfenicol compound composition and its preparation, can solve the problems of daily weight gain not meeting the standard, increased mortality, delayed slaughter time and the like, and achieve a specific long-acting therapeutic effect , The effect of improving economic efficiency and stability

Active Publication Date: 2015-04-08
河南后羿制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main clinical manifestations of affected pigs are cough, wheezing, growth retardation and low feed conversion rate
[0004] Pig respiratory disease is a common disease in poultry breeding and production. Pigs can be infected regardless of size, breed, age, etc., and the number of infected pigs is huge. The feed utilization rate of sick pigs is low, and the daily gain cannot reach the standard. The time is delayed, the cost of drugs increases, and the mortality rate increases, causing serious economic losses to farmers

Method used

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  • Florfenicol compound composition and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The florfenicol compound composition of the present embodiment is composed of: florfenicol 10g, azithromycin 5g, tylosin 2g, propylene glycol 40g, dimethylformamide 15g, α-pyrrolidone 25g, absolute ethanol 10g , Polyvinylpyrrolidone 3g.

[0023] The preparation method of florfenicol compound composition comprises the following steps:

[0024] 1) Take 15g of dimethylformamide, add 10g of florfenicol and stir to dissolve, then add 40g of propylene glycol, 25g of α-pyrrolidone, and 10g of absolute ethanol in sequence and stir until they are evenly mixed;

[0025] 2) Add 5g of azithromycin and 2g of tylosin and stir until evenly mixed;

[0026] 3) Heat and stir at 40°C, then add 3g of PVP K30, keep warm for reaction, continue to stir for 15 minutes after dissolving, to fully chelate between PVP K30 and the drug;

[0027] 4) Filter the obtained solution, flush with nitrogen, and potting to obtain the florfenicol compound composition.

Embodiment 2

[0029] The florfenicol compound composition of the present embodiment is composed of: florfenicol 10g, azithromycin 4g, tylosin 1.5g, propylene glycol 35g, dimethylformamide 17g, α-pyrrolidone 28g, absolute ethanol 9g, 2.5g of polyvinylpyrrolidone.

[0030] The preparation method of florfenicol compound composition comprises the following steps:

[0031] 1) Take 17g of dimethylformamide, add 10g of florfenicol and stir to dissolve, then add 35g of propylene glycol, 28g of α-pyrrolidone, and 9g of absolute ethanol in sequence and stir until they are evenly mixed;

[0032] 2) Add 4g of azithromycin and 1.5g of tylosin and stir until evenly mixed;

[0033] 3) Heat and stir at 40°C, then add 2.5g PVP K30, keep warm for reaction, continue to stir for 15 minutes after dissolving, so that PVP K30 and the drug can be fully chelated;

[0034] 4) Filter the obtained solution, flush with nitrogen, and potting to obtain the florfenicol compound composition.

Embodiment 3

[0036] The florfenicol compound composition of this embodiment is composed of: florfenicol 10g, azithromycin 3g, tylosin 1g, propylene glycol 30g, dimethylformamide 20g, α-pyrrolidone 30g, absolute ethanol 8g , Polyvinylpyrrolidone 2g.

[0037] The preparation method of florfenicol compound composition comprises the following steps:

[0038] 1) Take 20g of dimethylformamide, add 10g of florfenicol and stir to dissolve, then add 30g of propylene glycol, 30g of α-pyrrolidone, and 8g of absolute ethanol in turn and stir until they are evenly mixed;

[0039] 2) Add 3g of azithromycin and 1g of tylosin and stir until evenly mixed;

[0040] 3) Heat and stir at 40°C, then add 2g of PVP K30, keep warm for reaction, continue stirring for 15 minutes after dissolving, to fully chelate between PVP K30 and the drug;

[0041] 4) Filter the obtained solution, flush with nitrogen, and potting to obtain the florfenicol compound composition.

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Abstract

The invention discloses a florfenicol compound composition and a preparation method thereof. The composition is composed of florfenicol, azithromycin, tylosin, propylene glycol, dimethyl formamide, alpha-pyrrolidone, anhydrous ethanol and polyvinylpyrrolidone (PVP). The preparation method of the composition comprises steps of: 1) adding dimethyl formamide to florfenicol, stirring and dissolving; and sequentially adding propylene glycol, alpha-pyrrolidone and anhydrous ethanol, and stirring to mix evenly; 2) adding azithromycin and tylosin, and stirring to mix evenly; 3) heating with stirring at 40 DEG C, adding polyethylene pyrrole pyrrolidone, dissolving and continuing to stir for 15min; and 4) filtering the obtained solution, inflating nitrogen and encapsulating to obtain the florfenicol compound composition. The compound composition provided by the invention is mainly used in the treatment of swine respiratory diseases, and especially has specific long-term treatment effect and no recurrence on respiratory diseases, such as infectious pleuropneumonia, Haemophilus parasuis, swine plague and asthma.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a florfenicol compound composition and a preparation method thereof. Background technique [0002] As my country's livestock and poultry production intensifies and scales up, it is often easy to cause the prevalence of various infectious diseases. Clinically, especially a series of diseases caused by bacterial infections have brought great distress to farmers. Respiratory diseases of pigs caused by sensitive bacteria mainly include infectious pleuropneumonia, Haemophilus parasuis, porcine pneumonia, and panting disease. [0003] Porcine contagious pleuropneumonia is a serious contagious infectious disease of pig respiratory system caused by Actinobacillus pleuropneumoniae. Sudden death from sepsis. Haemophilus parasuis causes porcine polyserositis and arthritis, mainly in pigs after weaning in the nursery stage, usually seen in pigs aged 5 to 8 weeks, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7052A61K47/32A61P31/04A61P11/00A61P11/06A61K31/165A61K31/7048
Inventor 吴红云董晓盈赵丽
Owner 河南后羿制药有限公司
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