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Chimeric peptide based on opioid peptide Biphalin and neuropeptide FF, synthesis and application thereof

A technology of chimeric peptides and opioid peptides, applied in the field of biochemistry

Active Publication Date: 2014-05-21
SHANGHAI TIANCI LIFE SCI DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the analgesic activity of EN-9 is 4-10 times lower than that of the clinically used analgesic drug morphine, resulting in a higher effective analgesic dose than morphine

Method used

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  • Chimeric peptide based on opioid peptide Biphalin and neuropeptide FF, synthesis and application thereof
  • Chimeric peptide based on opioid peptide Biphalin and neuropeptide FF, synthesis and application thereof
  • Chimeric peptide based on opioid peptide Biphalin and neuropeptide FF, synthesis and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0082] The chimeric peptide synthesis method of the present invention will be further described through specific examples below.

[0083] I material

[0084] Instrument: High performance liquid chromatography (HPLC) is Delta 600 from Waters; analytical column: DELTA PAK 5μC18 300~3.9×150mm; preparative column: DELTA PAK 15μC18 300~7.8×300mm. The mass spectrometer was PE Biosystems, Mariner System 5074. Manual solid-phase peptide synthesizer, designed by our laboratory and made by a glass worker (for the design principle of the synthesizer, please refer to page 14 of "Fmoc solid phase peptide synthesis" edited by Chen WC and White PD Figure 4 , and some improvements were made on the basis of it, that is, the method of blowing nitrogen gas was replaced by mechanical stirring, so as to achieve the purpose of fully mixing the reaction solution). Reagent: The resin is Rink-Amide-MBHA-Resin (1% DVB, 200 ~ 400 mesh, substitution value S = 0.40 mmol / g resin), purchased from Tianjin...

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Abstract

Provided in the present invention is a chimeric peptide based on opioid peptide Biphalin and NPFF. Also provided in the present invention are the synthesis method for the chimeric peptide and the use thereof in preparing analgesic drugs. The chimeric peptide of the present invention has stronger central analgesic activity than morphine, and has the advantages of no analgesic tolerance, little effect on gastrointestinal motility, etc.

Description

Technical field [0001] The present invention is a biochemical technology field, which involves a churching peptide peptide and its synthesis method based on opioid peptides and neurotipptide FF; the present invention also involves the application of the cock peptide in high -efficiency, low side effects and analgesic preparation. Background technique [0002] Pain is one of the most common diseases that humans have experienced, and everyone will experience pain in their lives.According to statistics, about 1 / 3 people around the world endure the torture of persistent or periodic pain. Proc. Nat. Acad. Sci. U.S.A. 2001, 98: 11845).Clinically, morphine opioid drugs have been widely used in treatment and alleviating various pains, but because opioid analgesic drugs can cause severe tolerance, addiction, constipation, and respiratory suppression, so as to thusIt greatly limits its scope of clinical application. [0003] The existing research results show that opioid peptides in the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06C07K1/20C07K1/16C07K1/06C07K1/04A61K38/08A61P25/04
CPCA61K38/00C07K1/04C07K14/70C07K1/20A61K38/08C07K1/06C07K1/16C07K7/06C07K2319/00A61P25/04
Inventor 王锐方泉韩政岚王子龙李宁
Owner SHANGHAI TIANCI LIFE SCI DEV CO LTD
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