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Applications of 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide in preparation of neurological disease treatment products

A dioxyphenyl, disease technology, applied in nervous system diseases, drug combinations, active ingredients of heterocyclic compounds, etc., can solve even serious side effects and other problems

Active Publication Date: 2013-01-30
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, antipsychotic treatment may be associated with serious side effects such as tardive dyskinesia

Method used

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  • Applications of 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide in preparation of neurological disease treatment products
  • Applications of 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide in preparation of neurological disease treatment products
  • Applications of 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide in preparation of neurological disease treatment products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: 5-(3,4-methylenedioxyphenyl)-2E, 4E pentadienoic acid n-propanamine amide has monoamine oxidase inhibitory activity

[0020] 1. Materials:

[0021] 1.1 Animals: Wisteria rats, provided by the Animal Center of the Academy of Military Medical Sciences, certificate number: SCXK-(Army) 2002-001.

[0022] 1.2 Drugs and reagents Piperine (purchased from Beijing Pharmaceutical Purchasing and Supply Station), the purity is 98%. Thin-layer chromatography silica gel H (chemically pure, purchased from Qingdao Ocean Chemical Co., Ltd.); column chromatography silica gel (reagent grade, 200-300 mesh, purchased from Qingdao Ocean Chemical Co., Ltd.); thin-layer chromatography silica gel prefabricated plate (purchased Yantai Institute of Chemical Industry); PBS phosphate buffer (purchased from Beijing Solarbio); MAO-A inhibitor clorgyline, MAO-B inhibitor selegiline, MAO enzyme reaction substrate kynuramine dihydrobromide, standard 4-hydroxy quinoline (purchased from sigma...

Embodiment 2

[0040] Example 2: Research on antidepressant activity of 5-(3,4-methylenedioxyphenyl)-2E, 4E pentadienoic acid n-propylamine amide

[0041] 1. Materials:

[0042] 1.1 Animals 120 SPF grade Kunming mice (18-22g), all male.

[0043] 1.2 Drugs and reagents Piperine (Beijing Pharmaceutical Purchasing and Supply Station), with a purity of 98%. DMEM / F12 (1:1) medium (Hyclone Company); thiazolium blue (Merck Company); desipramine (purchased from Sigma Company); corticosterone (Sigma Company); fetal bovine serum (Hangzhou Sijiqing Bioengineering Materials Co., Ltd.); PBS (Beijing Solarbio Company); dimethyl sulfoxide (Beijing Chemical Reagent Company, batch number 060730); thionyl chloride (Beijing Chemical Reagent Company); sulfuric acid (Beijing Chemical Reagent Company); hydrochloric acid (Beijing Chemical Reagent Company); Reagent Company); trypsin (Beijing Trypsin Amresco0458 subpackage); penicillin, streptomycin (North China Pharmaceutical Co., Ltd.). Potassium hydroxide (Bei...

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Abstract

The present invention relates to uses of 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide in preparation of medicinal compositions for treatment and / or prevention of neuron diseases requiring neuroprotection effects and / or nerve regeneration. The 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide provides good treatment effects for depressions caused by various causes, provides significant anti-depression activity for a pharmacological depression model, provides a good protection effect for SH-SY5Y cells damaged by glutamic acid, and provides a selective inhibition effect for monoamine oxidase B (MAO-B).

Description

technical field [0001] The present invention relates to the application of 5-(3,4-methylenedioxyphenyl)-2E,4E n-propanylamine pentadienate in the preparation of products for treating and / or preventing neurological and / or psychiatric diseases. technical background [0002] Neurological disorders are medical conditions that include diseases or disorders that affect the nervous system. A neurological disorder may be pathological damage to the nervous system associated with a disease or disorder, or an improvement in neurological function to improve learning and memory in order to improve cognitive abilities. [0003] With the aging of the population, Alzheimer's disease (Alzheimer's disease, also known as Alzheimer's disease, hereinafter referred to as AD) has become a social problem that seriously endangers human health. The horror of this disease lies in its wide-ranging implications, because in addition to the severe loss of memory and cognitive ability of the patient himse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/36A61P25/28A61P25/24A61P25/00A61P25/18
Inventor 穆丽华刘屏胡园郭代红杨洁郭绍来
Owner GENERAL HOSPITAL OF PLA
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