Inhalation solutions

An inhaler, co-solvent technology for applications in the treatment of asthma, COPD (chronic obstructive pulmonary disease) and other breathing disorders, which can solve problems such as uninstructed doses

Inactive Publication Date: 2013-01-30
CIPLA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, none of the above prior art teaches reducing the dose of active agent administered by metered dose inhaler without compromising the FPD of the active agent particles / aerosol particles in the necessary formulations which are especially emphasized as in the International Parameters discussed in application PCT / EP98 / 03533

Method used

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Examples

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Embodiment Construction

[0031] As discussed herein, the inventors have surprisingly found that administration of a pressurized aerosol inhalable formulation comprising an active agent in solution via a low-porosity drive results in the desired FPD of the active agent particles / aerosol particles .

[0032]The low bore driver advantageously has a bore diameter of 0.2mm-0.4mm. Preferably, said diameter is 0.2mm to 0.33mm, more preferably 0.28mm to 0.33mm.

[0033] The inhalable solution according to the present invention may include one or more anticholinergic drugs, including tiotropium, ipratropium, oxitropium, aclidinium or their pharmaceutically acceptable salts and solvates , tautomers, derivatives, optical enantiomers, isomers, hydrates, prodrugs or polymorphs thereof.

[0034] Preferred salts are bromide salts, especially bromide salts of tiotropium, ipratropium, oxitropium and aclidinium. According to the invention, in a particularly preferred embodiment, the inhalation solution may comprise ...

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Abstract

A inhaler for an inhalation formulation, comprising a canister containing a pharmaceutical composition under pressure; a metering valve for measuring a metered dose of the composition from the canister for administration to a patient in need thereof; and an actuator for actuating discharge of the metered dose to the patient; wherein the actuator includes a discharge orifice having a diameter in the range 0.2 to 0.4 mm; and wherein the pharmaceutical composition comprises an anticholinergic agent and a pharmaceutically acceptable propellant.

Description

technical field [0001] The present invention relates to pressurized inhalation solutions, and methods for their preparation, and their use for the treatment of asthma, COPD (chronic obstructive pulmonary disease) and other breathing disorders. Background technique [0002] Knowledge of the size and distribution of particles produced by aerosol formulations is important both from a product optimization point of view and from the standpoint of potential inhalation characteristics such as certain actuator designs, valve characteristics, canister characteristics, etc. [0003] Metered dose inhalers (MDIs) are widely used in therapy, for example in the treatment of obstructive airway diseases and asthma, by administering aerosol formulations of pharmaceuticals in a pressurized manner. Inhalation provides a more rapid onset of action with minimal systemic side effects compared to oral administration. Aerosol formulations can be administered by inhalation through the mouth or by t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/46A61P11/06
CPCA61M15/009A61K31/439A61K9/008A61K31/46A61K45/06A61K47/02A61K47/06A61K47/10A61K47/12A61P11/06A61K2300/00A61M15/00A61M39/22A61K31/4748A61K9/12A61M11/04A61M15/0065
Inventor 阿马尔·卢拉吉纳·麦赫特拉
Owner CIPLA LTD
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