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Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers

A technique for rheumatic heart disease, patients, in the field of diagnosis and treatment of rheumatic heart disease based on group A streptococcal markers

Inactive Publication Date: 2013-02-27
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, there is no diagnostic method for individuals with RHD or at risk of developing RHD resulting from GAS infection

Method used

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  • Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers
  • Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers
  • Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers

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Embodiment Construction

[0232] preface

[0233] We have developed a protein microarray containing 130 recombinant GAS protein antigens. This chip facilitated the selection of antigens that elicited high antibody responses in pharyngitis patients and allowed to reveal the hyperresponsiveness to GAS antigens in sera of patients with Tic disease, strongly supporting that GAS antigen-dependent induction of autoantibodies in susceptible individuals may be involved in tic disorders Happens (Bombaci M, et al. 2009 PLoS ONE 4, 7: e6332.doi:10.1371).

[0234] We used protein microarrays to analyze the immune response to 130 recombinant GAS proteins in RHD patients and healthy donors, with the aim of identifying patterns of antigen recognition that would allow us to differentiate the two populations. This approach can identify antigenic groups that are highly recognized by healthy donors, but not RHD patients, which could provide the basis for a diagnostic test.

[0235] Materials and methods

[0236] human...

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Abstract

This invention is in the field of identifying patients having rheumatic heart disease (RHD) associated with Streptococcus pyogenes (Group A Streptococcus; GAS) infection and identifying patients at risk of developing RHD associated with GAS infection. The invention also provides methods and compositions for preventing and treating RHD associated with GAS infection.

Description

technical field [0001] The present invention is in the field of identifying patients with rheumatic heart disease (RHD) associated with Streptococcus pyogenes (group A streptococcus: GAS) infection and identifying patients at risk of developing RHD associated with GAS infection. The present invention also provides methods and compositions for preventing and treating RHD associated with GAS infection. technical background [0002] The human pathogenic group A streptococcus (Streptococcus pyogenes, GAS) is widely recognized as a major cause of common pharyngitis. Infection with this bacterium can also cause severe invasive disease and nonsuppurative autoimmune sequelae. Acute rheumatic fever (ARF) is a multifocal autoimmune disease that occurs in 0.1–3% of untreated GAS-infected individuals. [0003] ARF is diagnosed by the updated Jones criteria, first published in 1944. According to the updated Jones criteria, when there are two major criteria (migratory polyarthritis; ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569G01N33/564
CPCG01N33/56944G01N2800/32G01N33/564G01N2800/24A61P9/00A61P29/00A61P31/04A61P37/04
Inventor I·马格丽特伊若斯R·瓦莱里奥S·阿罕默德G·格兰迪E·巴尔托利尼
Owner NOVARTIS AG
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