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Polyferose controlled-release pellet and preparation method thereof

A technology for slow-release pellets and polysaccharide iron, applied in the field of medicine, can solve the problems of rapid increase in plasma concentration, etc., and achieve the effects of avoiding the peak-to-valley phenomenon of blood drug concentration, effective absorption, and simple preparation method.

Active Publication Date: 2015-03-18
QINGDAO HUANGHAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gastrointestinal side effects of polysaccharide iron immediate-release preparation may be caused by rapid increase in plasma concentration

Method used

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  • Polyferose controlled-release pellet and preparation method thereof
  • Polyferose controlled-release pellet and preparation method thereof
  • Polyferose controlled-release pellet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The contents of the principal ingredient and auxiliary materials in the polysaccharide iron sustained-release preparation are as follows:

[0036] The composition of the pill core containing medicine is: 350 parts of polysaccharide iron, 35 parts of hypromellose E5 and 160 parts of blank ball core;

[0037] The composition of the delayed release film coat was: 29.17 parts ethylcellulose, 2.92 parts hypromellose E5 and 2.92 parts castor oil.

[0038] The preparation method of the polysaccharide iron sustained-release pellets comprises the following steps:

[0039] (1) Preparation of drug-containing pill cores: take the polysaccharide iron, blank pellet cores and hypromellose E5 in the ratio described above, add hypromellose E5 into an appropriate amount of hot water to disperse, cool to dissolve, and prepare Containing the adhesive of 3% hypromellose E5, adding the blank ball core in the centrifugal granulator, spraying the adhesive while carrying out the polysaccharide...

Embodiment 2

[0054] The contents of the principal ingredient and auxiliary materials in the polysaccharide iron sustained-release preparation are as follows:

[0055] The composition of the pill core containing medicine is: 350 parts of polysaccharide iron, 35 parts of hypromellose E5 and 148 parts of blank ball core;

[0056] The composition of the sustained release film coat was: 35.83 parts ethyl cellulose, 3.58 parts polyethylene glycol 1500 and 3.58 parts castor oil.

[0057] The preparation method of the above-mentioned polysaccharide iron sustained-release pellets comprises the following steps:

[0058] (1) Preparation of drug-containing pill cores: take the polysaccharide iron, blank pellet cores and hypromellose E5 in the ratio described above, add hypromellose E5 into an appropriate amount of hot water to disperse, cool to dissolve, and prepare Contain the binder of 3% hypromellose E5, add the blank pellet core in the centrifugal granulator, spray the binder while carrying out t...

Embodiment 3

[0063] The contents of the principal ingredient and auxiliary materials in the polysaccharide iron sustained-release preparation are as follows:

[0064] The composition of the pill core is: 350 parts of polysaccharide iron, 35 parts of hypromellose E5 and 167 parts of blank pill core;

[0065] The sustained-release film coating consisted of: 23.33 parts of cellulose acetate, 2.33 parts of polyethylene glycol 1500 and 2.33 parts of castor oil.

[0066] The preparation method of the above-mentioned polysaccharide iron sustained-release pellets comprises the following steps:

[0067] (1) Preparation of drug-containing pill cores: take the polysaccharide iron, blank pellet cores and hypromellose E5 in the ratio described above, add hypromellose E5 into an appropriate amount of hot water to disperse, cool to dissolve, and prepare Contain the binder of 3% hypromellose E5, add the blank pellet core in the centrifugal granulator, spray the binder while carrying out the polysaccharid...

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Abstract

The invention provides a polyferose controlled-release pellet and a preparation method thereof. The polyferose controlled-release pellet consists of a pill core and a controlled-released film cover, wherein the medicine-contained pill core consists of 350 parts of polyferose, 1-50 parts of adhesives and 50-250 parts of blank pill cores; the controlled-released film cover consists of 5-50 parts of controlled-release materials, 0.5-10 parts of pore-foaming agent and 0.5-10 parts of plasticizer. According to the polyferose controlled-release pellet, drugs can be released durably and slowly, the blood concentration is stable, the fluctuation is slight, the phenomenon of blood concentration peak of quick-acting preparation can be avoided, the strong stimulation on the gastrointestinal tract caused by overhigh local drug concentration can be avoided, and the side effect to the gastrointestinal tract is small; the effective lasting time is long, people only need to take the pellet for one time every day, and can take the pellet conveniently; a human body can absorb the pellet effectively, the absorbing individual difference is small, and the good effect can be achieved; and the preparation method is simple, the reproducibility is good, and the pellet is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a polysaccharide iron sustained-release pellet preparation and a preparation method thereof. Background technique [0002] Iron deficiency anemia refers to the imbalance between the body's demand and supply of iron, leading to the depletion of iron storage in the body, followed by anemia caused by iron deficiency in red blood cells. Iron deficiency anemia is the most common type of anemia. Iron deficiency anemia can occur in all age groups of different sexes, especially in women of reproductive age with the highest incidence. Anemia in pregnancy is common and severe, and iron deficiency anemia accounts for about 90%. Severe anemia can lead to perinatal and maternal mortality. Patients with iron deficiency anemia may have symptoms such as fatigue, tiredness, dizziness, growth retardation in children, mental retardation, and susceptibility to infection, and should b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/715A61P7/06
Inventor 刘少梅尤恒张兴跃徐晓琳于华芝鲁大东
Owner QINGDAO HUANGHAI PHARM CO LTD
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