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Compound florfenicol and neomycin sulfate nanoemulsion formulation and preparation method thereof

A technology of compound florfenicol and neomycin sulfate, which is applied in the fields of pharmaceutical formula, emulsion delivery, medical preparations containing active ingredients, etc., and can solve the compound nano Research and application of milk preparations and other issues, to achieve the effect of facilitating large-scale industrial production, low production cost, and improving drug utilization

Inactive Publication Date: 2013-03-20
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no compound nanoemulsion preparation of florfenicol and neomycin sulfate has been studied and applied

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of Compound Florfenicol and Neomycin Sulfate Nanoemulsion

[0026] Prepare the recipe as follows:

[0027] Florfenicol 0.2g

[0028] Neomycin Sulfate 1.0 g

[0029] Dimethylformamide 1.0 g

[0030] Tween 80 3.5 g

[0031] Peppermint oil 0.4 g

[0032] Distilled water 5.0 g

[0033] The specific operation steps are:

[0034] Take each raw material in proportion; after dissolving Florfenicol in dimethylformamide, mix with Tween 80 and peppermint oil, it is mixture A; dissolve neomycin sulfate in distilled water, and it is mixture B; at room temperature Slowly add mixture B to mixture A dropwise, while stirring continuously, until a uniform and transparent system is formed, and the target product is obtained.

Embodiment 2

[0036] Preparation of Compound Florfenicol and Neomycin Sulfate Nanoemulsion

[0037] Prepare the recipe as follows:

[0038] Florfenicol 0.1 g

[0039] Neomycin sulfate 0.2 g

[0040] Dimethyl sulfoxide 0.8 g

[0041] Pinpinga O 3.0 g

[0042] Peppermint oil 0.3 g

[0043] Distilled water 4.0 g

[0044] The specific operation steps are:

[0045] Take each raw material in proportion; after dissolving florfenicol in dimethyl sulfoxide, mix it with Pingpinga O and peppermint oil to form mixture A; dissolve neomycin sulfate in distilled water to form mixture B ; Slowly add the mixture B to the mixture A at room temperature while stirring continuously until a uniform and transparent system is formed to obtain the target product.

Embodiment 3

[0047] Preparation of Compound Florfenicol and Neomycin Sulfate Nanoemulsion

[0048] Prepare the recipe as follows:

[0049] Florfenicol 0.005 g

[0050] Neomycin sulfate 0.005 g

[0051] Dimethyl sulfoxide 0.035 g

[0052] RH40 2.5g

[0053] Peppermint oil 0.15 g

[0054] Distilled water 3.0 g

[0055] The specific operation steps are:

[0056] Take each raw material in proportion; after dissolving Florfenicol in dimethyl sulfoxide, mix it with RH40 and peppermint oil to form mixture A; dissolve neomycin sulfate in distilled water to form mixture B; Slowly add B into the mixture A while stirring continuously until a uniform and transparent system is formed, and the target product is obtained.

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Abstract

The invention belongs to the field of veterinary medicine, and in particular relates to a compound florfenicol and neomycin sulfate nanoemulsion formulation with high stability and a good absorption effect and a preparation method thereof. The nanoemulsion formulation is of oil-in-water type with a particle size of 1-100 nm, and is prepared from florfenicol, neomycin sulfate, a cosolvent, a surfactant, a cosurfactant, oil and distilled water. The invention is simple in preparation process, low in production cost, good in drug absorption effect, and improved in drug utilization; the method uses nanoemulsion as a drug carrier; and the formulation has the advantages of broad spectrum, efficiency, target, sustained release, security, etc. and is significant in the effect of treatment of bacterial infection.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a compound florfenicol and neomycin sulfate nano-emulsion preparation and a preparation method thereof. Background technique [0002] Both florfenicol and neomycin sulfate are antibacterial drugs widely used clinically. They have the characteristics of broad antibacterial spectrum, strong bactericidal power and rapid action. They are widely used to treat sensitive animals such as respiratory system, urogenital system, skin and soft tissue. bacterial infection. However, due to long-term and extensive use, many pathogenic bacteria have developed certain resistance to these two drugs. In CN102068443A, florfenicol and neomycin sulfate are used in combination to prepare an ultrafine powder to enhance the curative effect, reduce the dosage, and have better curative effect on aquatic bacterial diseases. However, the powder in the prior art needs to be mixed with drinking water and t...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K31/165A61K9/107A61P31/04
Inventor 胡帅樊楠梁军李坤鹏
Owner HENAN SOAR VETERINARY PHARMA
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