Elastic polyurethane antibacterial material and preparation method thereof

A technology of elastic polyurethane and antibacterial materials, which is applied in the direction of pharmaceutical formulations and medical preparations of non-active ingredients, etc., can solve the problems of affecting the physical and mechanical properties of polymer materials, and the loss of use value of materials, so that the use value is not affected, good Physico-mechanical properties, effects of improving mechanical properties and deformation resistance

Active Publication Date: 2020-11-10

浙江德美博士达高分子材料有限公司

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AI-Extracted Technical Summary

Problems solved by technology

In addition, traditional polymers generally achieve ROS-responsive drug release through the breakage of polymer chain segments, which seriously affects the physical and mechanical pr...

Abstract

The invention discloses an elastic polyurethane antibacterial material and a preparation method thereof. The preparation method comprises the steps: subjecting tartaric acid and polyhydric alcohols toa catalytic reaction to obtain modified polyhydric alcohols, then adding an antibacterial agent and an emulsifier into the modified polyhydric alcohols, feeding nitrogen for cooling after a period ofhigh-temperature reaction, adding polyisocyanate and a chain extender into the reactants, and terminating with gastrodin to obtain the elastic polyurethane antibacterial material. The antibacterial material disclosed by the invention can generate ROS stimulation response in the presence of bacteria, so that the medicine utilization rate is effectively improved. The tartaric acid provided by the invention has a large number of active functional groups, a cross-linked network structure can be formed, the cross-linking density of the network structure can be changed by adjusting the proportion of synthetic raw materials, and the drug release rate during response of the antibacterial material is regulated and controlled. The added gastrodin can improve the mechanical property and the deformation resistance of the polyurethane antibacterial material, so that the polyurethane antibacterial material still has good physical and mechanical properties after chemical bonds are broken in the ROSresponse drug release process.

Application Domain

Pharmaceutical non-active ingredients

Technology Topic

Drug release rateChemical bond +11

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Examples

Experimental program(4)

Example Embodiment

[0023] Example 1

[0024] A preparation method of elastic polyurethane antibacterial material, comprising the steps of:

[0025] 1) Preparation of modified polypolyol

[0026] Add 15 parts by weight of tartaric acid and 150 parts by weight of polyethylene glycol with a molecular weight of 200-600 in a four-necked round bottom flask, then add 3 parts of catalyst 4-dimethylaminopyridine, and then keep the reactant at 60 ° C React for 1.5 hours; then raise the temperature to 120°C at a rate of 2°C per minute, and keep the temperature for 1 hour; finally cool the reaction mixture to 20°C to obtain the modified polypolyol;

[0027] 2) Preparation of polyurethane

[0028] Add 3 parts by weight of carvone and 2 parts by weight of emulsifier N-methyldiethanolamine to 30 parts by weight of modified polyol prepared in 1), and stir at 110° C. for 1.5 hours; then feed nitrogen into the reaction vessel Cool to 30°C; then add 55 parts by weight of hexamethylene diisocyanate and heat up to 60°C; add 1 part by weight of catalyst dimethylacetamide to the reaction vessel, then add 5 parts by weight of ketal thioketal and 25 parts by weight of gastrodin, after continuous heating for 1.5 hours, cooled to room temperature to obtain elastic polyurethane antibacterial material.

Example Embodiment

[0029] Example 2

[0030] A preparation method of elastic polyurethane antibacterial material, comprising the steps of:

[0031] 1) Preparation of modified polypolyol

[0032] Add 20 parts by weight of tartaric acid and 200 parts by weight of polypropylene glycol with a molecular weight of 400-2000 in a four-necked round bottom flask, then add 5 parts by weight of catalyst 4-dimethylaminopyridine, and then continue the reaction at 70 ° C 2.5 hours; then raise the temperature to 130°C at a rate of 3°C per minute, and keep the temperature for 2 hours; finally cool the reaction mixture to 30°C to obtain the modified polyol;

[0033] 2) Preparation of polyurethane

[0034] Add 5 parts by weight of cinnamaldehyde and 4 parts by weight of emulsifier N-methyldiethanolamine to 40 parts by weight of modified polyol prepared in 1), and stir at 120° C. for 2.5 hours; then feed nitrogen into the reaction vessel for cooling to 40°C; then add 60 parts by weight of cycloaliphatic diisocyanate, and heat up to 70°C; then add 1.5 parts by weight of catalyst dimethylacetamide to the reaction vessel, then add 6.5 parts by weight of ketal and gastrodin 35 parts by weight, after continuous heating for 2 hours, cool to room temperature to obtain an elastic polyurethane antibacterial material.

Example Embodiment

[0035] Example 3

[0036] A preparation method of elastic polyurethane antibacterial material, comprising the steps of:

[0037] 1) Preparation of modified polypolyol

[0038] Add the polyethylene adipate glycol of the tartaric acid of 25 weight parts and the molecular weight 400-1500 of 250 weight parts in the four-neck round bottom flask, add the catalyst 4-dimethylaminopyridine of 6 weight parts again, then will The reactant was continuously reacted at 80°C for 3.5 hours; then the temperature was raised to 135°C at a rate of 4°C per minute, and the temperature was kept for 3 hours; finally, the reaction mixture was cooled to 40°C to obtain the modified polypolyol;

[0039] 2) Preparation of polyurethane

[0040]Add 8 parts by weight of citral and 5 parts by weight of emulsifier N-methyldiethanolamine to 45 parts by weight of modified polyol prepared in 1), and stir for 4 hours at 140°C; then feed nitrogen into the reaction vessel for cooling to 50°C; then add 65 parts by weight of isophorone diisocyanate, and heat up to 85°C; then add 2.5 parts by weight of catalyst dimethylacetamide to the reaction vessel, then add 7 parts by weight of ketal ketal and Gastrodia elata 50 parts by weight of element, after continuous heating 3.5 hours, be cooled to room temperature, obtain elastic polyurethane antibacterial material.

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Classification and recommendation of technical efficacy words

Improve drug utilization
Good biocompatibility and degradability

Elastic polyurethane antibacterial material and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

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Examples

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Description & Claims & Application Information

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