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Chuju total flavone granule and its preparation method and application

A technology of total flavonoids and chrysanthemum, which is applied in the fields of application, food preparation, and pharmaceutical formulations, can solve the problems of component loss and easy discoloration during soaking time, and achieve the effects of easy preservation, improvement of abnormal blood rheology, and convenient portability

Active Publication Date: 2014-10-08
ANHUI JUTAI CHUJU HERBAGE TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims at the problems of discoloration and component loss in the storage process of chrysanthemum chrysanthemum, as well as the easy discoloration when soaking for too long, extracts total flavonoids from chrysanthemum chrysanthemum, prepares dry extract of total flavonoids, and uses powdered sugar and dextrin as auxiliary materials Preparation of total flavone granules, Chuju total flavone granules

Method used

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  • Chuju total flavone granule and its preparation method and application

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Effect test

Embodiment 1

[0013] 70% ethanol was used as the extraction solvent, the ratio of solid to liquid was 1:20 (mass ratio of dry leaves of Chrysanthemum chrysanthemum to solvent volume, g / ml), the extraction time was 1 h, the extraction temperature was 60 °C, and the extraction was performed twice. The extract containing the total flavonoids of Chuju chrysanthemum was extracted from the leaves, concentrated to remove the solvent, and then dried under reduced pressure at 50° C. to prepare the dry extract powder of the total flavonoids of Chuju chrysanthemum.

Embodiment 2

[0015] Take by weighing sucrose powder: dextrin: dry extract powder=1.0: 2.0: 1.0 mass ratio takes Chuju total flavonoids dry extract powder, sucrose powder and dextrin, after making soft material with 70% ethanol wetting, extrude Press through a 14-mesh sieve to granulate. After drying, pass through a 20-mesh sieve for granulation, and then pass through a 45-mesh sieve to remove fine powder to obtain dry granules with uniform particle size. Divide into 10g per bag. The granules prepared by the preparation process have better mouthfeel. The prepared chrysanthemum total flavonoid granules are light yellow and white in color, sweet and slightly bitter, with chrysanthemum fragrance, uniform in color, similar in size, good formability, uniform in particle size and good in taste. The particle size meets the particle size measurement requirements of Appendix I of the Chinese Pharmacopoeia 2010 Edition (less than 15%), and the moisture content meets the drying method determination i...

Embodiment 3

[0051] Take by weighing sucrose powder: dextrin: dry extract powder=0.5: 1.5: 0.5 mass ratio takes Chuju total flavonoids dry extract powder, sucrose powder and dextrin, after making soft material with 70% ethanol wetting, extrude Press through a 14-mesh sieve to granulate. After drying, pass through a 20-mesh sieve for granulation, and then pass through a 45-mesh sieve to remove fine powder to obtain dry granules with uniform particle size. Divide into 10g per bag. The granules prepared by the preparation process have better mouthfeel. The prepared chrysanthemum total flavonoid granules are light yellow and white in color, sweet and slightly bitter, with chrysanthemum fragrance, uniform in color, similar in size, good formability, uniform in particle size and good in taste. The particle size meets the particle size measurement requirements of Appendix I of the Chinese Pharmacopoeia 2010 Edition (less than 15%), and the moisture content meets the drying method determination i...

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Abstract

The invention discloses a chrysanthemum total flavone granule, which is made of the following raw materials in the weight ratio: sucrose powder: dextrin: dry extract powder of the total flavonoids of chrysanthemum = 0.5-1.5: 1.5-2.5: 0.5-1.5 . The present invention prepares chrysanthemum total flavonoids into granules. The granules have good formability, properties, particle size, water content, solubility, etc. all meet the requirements, and the quality is controllable and the stability is good. The color changes, the smell is lost, the content of active ingredients decreases, and the color of the item in the soaking process does not turn green. Chuju total flavonoids granules can significantly prolong the coagulation time of rats with cold coagulation and blood stasis syndrome, reduce the length of thrombus in vitro and dry and wet weight, reduce hematocrit, slow down erythrocyte sedimentation rate, and increase serum NO content. The product is easy to drink and carry, easy to store, has no toxic and side effects, and has the characteristics of preventing, treating and improving abnormal blood rheology in rats with blood stasis.

Description

technical field [0001] The invention relates to a preparation process and application of traditional Chinese medicine granules, in particular to a preparation method, quality control and application of Chuju total flavonoids granules. Background technique [0002] Chuju is the dry flower head of Chuju (Dendranthemum morifolium Ramat.), which is produced in Chuzhou, Anhui. Heat dissipation, eyesight detoxification and other effects. "Compendium of Materia Medica Supplements" records: "Chamomile, produced in Chihe, Anhui, is used as medicine." Chrysanthemum chrysanthemum tastes pungent, sweet, bitter, and slightly cold in nature. It has the effects of dispelling wind-heat, calming liver yang, clearing liver and improving eyesight, clearing away heat and detoxification, especially for calming liver yang, and is often used to treat dizziness caused by hyperactivity of liver yang dizziness embolism. "Modern Practical Chinese Medicine" (edited by Ye Juquan) contains chrysanthem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/287A61K9/16A23L1/29A61P7/02A23L33/00
Inventor 俞浩史亚东肖新
Owner ANHUI JUTAI CHUJU HERBAGE TECH
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