Biomarkers for the treatment of psoriasis
A psoriasis, biological sample technology, applied in biological testing, biological material analysis, drug combination and other directions, can solve the problem of low expression level of anti-inflammatory cytokine IL-10
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[0388] Y is i) phenyl or heterocyclic ring, which is unsubstituted or substituted by one or more substituents each independently selected from the group consisting of nitro, cyano, trifluoromethyl, ethoxycarbonyl, Methoxycarbonyl, propoxycarbonyl, acetyl, carbamoyl, acetoxy, carboxyl, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, or halogen, or ii) naphthyl. Specific examples of compounds have the formula:
[0389]
[0390] in:
[0391] Ar is 3,4-disubstituted phenyl, wherein each substituent is independently selected from: nitro, cyano, trifluoromethyl, ethoxycarbonyl, methoxycarbonyl, propoxycarbonyl, acetyl, amino formyl, acetoxy, carboxyl, hydroxyl, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, and halogen;
[0392] Z is alkoxy, benzyloxy, amino or alkylamino of 1 to 10 carbon atoms; and
[0393] Y is (i) unsubstituted phenyl or phenyl substituted by one or more substituents independently selected from the gro...
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