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Biomarkers for the treatment of psoriasis

A psoriasis, biological sample technology, applied in biological testing, biological material analysis, drug combination and other directions, can solve the problem of low expression level of anti-inflammatory cytokine IL-10

Active Publication Date: 2013-04-03
AMGEN (EURO) GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, low expression levels of the anti-inflammatory cytokine IL-10 were observed in psoriatic lesions

Method used

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  • Biomarkers for the treatment of psoriasis
  • Biomarkers for the treatment of psoriasis
  • Biomarkers for the treatment of psoriasis

Examples

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[0388] Y is i) phenyl or heterocyclic ring, which is unsubstituted or substituted by one or more substituents each independently selected from the group consisting of nitro, cyano, trifluoromethyl, ethoxycarbonyl, Methoxycarbonyl, propoxycarbonyl, acetyl, carbamoyl, acetoxy, carboxyl, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, or halogen, or ii) naphthyl. Specific examples of compounds have the formula:

[0389]

[0390] in:

[0391] Ar is 3,4-disubstituted phenyl, wherein each substituent is independently selected from: nitro, cyano, trifluoromethyl, ethoxycarbonyl, methoxycarbonyl, propoxycarbonyl, acetyl, amino formyl, acetoxy, carboxyl, hydroxyl, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, and halogen;

[0392] Z is alkoxy, benzyloxy, amino or alkylamino of 1 to 10 carbon atoms; and

[0393] Y is (i) unsubstituted phenyl or phenyl substituted by one or more substituents independently selected from the gro...

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Abstract

Provided herein are the biomarkers for predicting or monitoring the efficacy of a treatment for psoriasis. The use of certain cell markers and mRNA levels as biomarkers to predict whether a psoriasis treatment is likely to be successful is also provided. Further, the expression of these genes or cell markers can be used to monitor progress of treatment effectiveness and patient compliance in psoriasis patients who are receiving treatment.

Description

1. Technical field [0001] Provided herein is the monitoring of specific biomarkers in samples obtained from skin biopsies before and during treatment of psoriasis. Also provided herein is monitoring of the expression of one or more specific genes or proteins prior to and during treatment. 2. Background technology [0002] Psoriasis is a chronic autoimmune inflammatory skin disease characterized by epidermal hyperproliferation of keratinocytes and endothelial cells and accumulation of inflammatory cells such as activated T cells. Griffiths CE, J. Eur. Acad. Dermatol. Venereol. 2003, 17 Suppl 2: 1-5; Creamer JD et al., Clin. Exp. Dermatol. 1995, 20(1): 6-9. In addition, recent evidence implicates the involvement of natural killer cells (NK) and NK T cells in the pathogenesis of psoriasis, as these cells produce interferon-γ (IFN-γ), which has been shown to be involved in silver Play a role in the proliferation of psoriatic keratinocytes. Bos JD et al., Br. J. Dermatol. 2005...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N2333/70525G01N2333/7051G01N2333/70539G01N2800/205G01N33/5044G01N2333/70596G01N33/5091G01N2800/52A61P17/06A61P17/10G01N33/48
Inventor 彼得·H·谢弗勇·林唐纳·萨瑟兰
Owner AMGEN (EURO) GMBH
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