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Preparation technology and production method of integrative new dosage form of Pinellia Tuber powder

A production method and a technology for a new dosage form, which are applied in the field of the preparation of a new integrated dosage form of Banxia powder to achieve the effects of strong sustained and controlled release performance and wide targeted distribution.

Inactive Publication Date: 2013-04-10
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] 8. Toxicity: The LD50 of a single intraperitoneal injection of pinellia soaked mice is 325mg (crude drug) / Kg. Each mouse is given 0.5g orally per day for 40 consecutive days. The general condition is good and the body weight increases, but when the dose is doubled, it will cause diarrhea. , half of them died, and the pathological examination showed that the color of the smooth wall was darker.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0062] The composition of the raw materials used to make the active ingredients is——

[0063] Pinellia 15 parts, Gui Zhi 15 parts, Zhi Licorice 15 parts.

[0064] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report.

Embodiment 2

[0066] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0067] The composition of the raw materials used to make the active ingredients is——

[0068] Pinellia 15 parts, Gui Zhi 15 parts, Zhi Licorice 15 parts.

[0069] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issu...

Embodiment 3

[0071] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0072] The composition of the raw materials used to make the active ingredients is——

[0073] Pinellia 15 parts, Gui Zhi 15 parts, Zhi Licorice 15 parts.

[0074] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 1272 hours. The application site: neck, chest, back, abdomen, legs, soles of the feet, ...

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Abstract

The invention relates to a preparation technology and a production method of an integrative new dosage form of Pinellia Tuber powder. The raw materials for the effective components of the powder comprise 15 parts by weight of Pinellia Tuber, 15 parts by weight of cassia twig and 15 parts by weight of honey-fried licorice root. The production method comprises the production processes of ultrasonic airflow crushing, alcohol-water extraction, supersonic wave crushing extraction, water decoction and concentration, ultrasonic spray drying, nanometer grinding, high-pressure homogenization, nanoparticle preparation and the like. The advantages comprising multiple cooperation, multiple targeting and the like of a nanometer carrier combination technology are utilized in the invention. Great production cost reduction, great product quality improvement, medicine targeting strengthening, and medicine sustained and controlled release property strengthening are realized after the large-scale production. Internal and external administration can be simultaneously carried out, and the powder can be respectively administrated in four time periods according to the midnight-noon ebb-flow and human qi and blood flow rules. The powder can also be processed to prepare a film agent and a transdermal agent which are respectively plastered on different positions of a human body according to the midnight-noon ebb-flow and human qi and blood flow rules, and the effective components can be directly absorbed through skins.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Banxia powder, and also relates to a preparation technology of a new integrated dosage form of Banxia powder and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reductio...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/00A61P11/04
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH