Isolates of hedysari polybotrys polysaccharide 3 and application thereof

A technology of Hengqi polysaccharide and medicine, applied in the field of natural medicinal chemistry

Active Publication Date: 2015-02-25
GANSU PUERKANG PHARMA CO LTD
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  • Abstract
  • Description
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Problems solved by technology

However, there are no reports at home and abroad about the anti-aging and anti-radiation effects of Astragalus polysaccharides.

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  • Isolates of hedysari polybotrys polysaccharide 3 and application thereof
  • Isolates of hedysari polybotrys polysaccharide 3 and application thereof
  • Isolates of hedysari polybotrys polysaccharide 3 and application thereof

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Embodiment Construction

[0250] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0251] (1) Extraction of Astragalus polysaccharide 3

[0252] After the Radix Radix Radix is ​​crushed, degrease with 95% ethanol for 1-3 hours. 5 to 20 times the amount of water, extract 1 to 5 times at 40 to 100 ° C, each time for 1 to 3 hours. Combine the extracts and concentrate to a certain volume. The concentrated solution is first precipitated with ethanol with a final concentration of 0-70%, filtered, and precipitated; the supernatant after the precipitation is re-precipitated with ethanol with a final concentration of 20%-80%; Precipitate with 30%-90% ethanol, filter, and freeze-dry the precipitate to obtain Heqi polysaccharide 3 (HPS-3).

[0253] (2) Se...

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Abstract

The invention provides four isolates of hedysari polybotrys polysaccharide 3, and researches on physical and chemical properties (including molecular weight and distribution, conformation, composite, polysaccharide content and protein content), chemical structure and anti-aging effect of the four isolates. Moreover, a pharmacology experiment discovers that the four uniform hedysari polybotrys polysaccharide components have remarkable anti-aging effect on D-gal aging mice, and have good effects of regulating blood sugar level, reducing blood fat, resisting radiation and improving immunity on experimental type 2 diabetic rats. Simultaneously, the invention further provides corresponding preparation methods and pharmaceutical preparations of the isolates of hedysari polybotrys polysaccharide 3.

Description

technical field [0001] The invention relates to the isolate of Heqi polysaccharide 3 and its application, and belongs to the technical field of natural medicinal chemistry. Background technique [0002] Radix Hedysari (Radix Hedysari) is the root of Hedysarum polybotrys Hand.-Mazz, a plant of the genus Hedysarum polybotrys Hand.-Mazz in the leguminous family. Sugar, diuretic, anti-viral, anti-aging and other effects. Astragalus polysaccharide is one of its main active ingredients, and the HPS-3 part has obvious hypoglycemic and antioxidative effects in vitro. [0003] At present, there have been more detailed reports on the chemical constituents of Radix Astragali at home and abroad, but the research on polysaccharides of Radix Radix Radix is ​​still limited to the primary structure and some pharmacological effects. In 1997, Liu Fangming of Lanzhou University extracted and isolated a homopolysaccharide-dextran from Radix Radix Radix Radix, and studied its structure; The m...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61K31/737A61P39/00A61P37/04A61P3/10A61P3/06
Inventor 封士兰赵良功封德梅陈同强刘小花李文崔方党子龙石义凯
Owner GANSU PUERKANG PHARMA CO LTD
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