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Recombinant human insulin sustained-release tablet and preparation method thereof

A technology of recombinant human insulin and sustained-release tablets, which is applied in the field of medicine, can solve the problems of weak curative effect, weak drug effect, increased dose, etc., and achieves the effects of reducing fasting blood sugar level, high encapsulation rate, and long action time.

Inactive Publication Date: 2015-04-08
江西宇骏生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Traditional recombinant human insulin preparations only use recombinant human insulin as the main component, and the drug effect is weak and the efficacy persistence is weak. Patients need to inject or take it for a long time, and after long-term use, the dose will continue to increase, which brings great trouble and inconvenience to patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A recombinant human insulin sustained-release tablet, comprising the following raw materials in the following weight ratio: 9 parts of Zhimu, 7 parts of Radix Astragali, 4 parts of tea oil seed, 13 parts of recombinant human insulin, 24 parts of lecithin, 7 parts of cholesterol, collagen 4 parts, vitamin E 1.0 part, chitosan 0.5 part;

[0023] The specific preparation method is as follows:

[0024] Preparation of Anemarrhena extract: Take Anemarrhena and crush it to 200 meshes, add 80% ethanol solution with a mass fraction 15 times the mass of Anemarrhena, extract twice at 60°C for 2 hours each time, combine the two extracts, and filter to obtain Crude extract of Anemarrhena, the crude extract was passed through a D101 macroporous adsorption resin column, the sample loading flow rate was 1.4BV / h, and it was eluted with 2.9BV of ethanol solutions with mass fractions of 35%, 55%, and 65%, respectively, and the flow rate of alcohol washing was 2.4BV / h, collect the eluate,...

Embodiment 2

[0032] A recombinant human insulin sustained-release tablet, comprising the following raw materials in weight ratio: 8 parts of Anemarrhena, 6 parts of Astragalus, 3 parts of tea oil seed, 11 parts of recombinant human insulin, 22 parts of lecithin, 6 parts of cholesterol, collagen 3 parts, 0.8 parts of vitamin E, 0.4 parts of chitosan;

[0033] The specific preparation method is as follows:

[0034] Preparation of Anemarrhena extract: Take Anemarrhena and crush it to 200 meshes, add 75% ethanol solution with a mass fraction 12 times the mass of Anemarrhena, extract twice at 55°C for 1 hour each time, combine the two extracts, and filter to obtain Anemarrhena crude extract, the crude extract is passed through D101 macroporous adsorption resin column, the sample loading flow rate is 0.8BV / h, and the ethanol solutions with mass fractions of 35%, 55%, and 65% are eluted with 2.5BV each, and the flow rate of alcohol washing is 1.6BV / h, collect the eluent, after the eluent is deco...

Embodiment 3

[0042] A recombinant human insulin sustained-release tablet, comprising the following raw materials in weight proportions: 12 parts of Zhimu, 8 parts of Radix Astragali, 5 parts of tea oil seed, 15 parts of recombinant human insulin, 30 parts of lecithin, 10 parts of cholesterol, collagen 6 parts, vitamin E 1.2 parts, chitosan 0.7 parts;

[0043] The specific preparation method is as follows:

[0044] Preparation of Anemarrhena extract: Take Anemarrhena and crush it to 200 mesh, add an ethanol solution with a mass fraction of 16 times the mass of Anemarrhena and extract 2 times at 65°C for 3 hours each time, combine the two extracts, and filter to obtain The crude extract of Anemarrhena, the crude extract was passed through a D101 macroporous adsorption resin column, the sample loading flow rate was 1.8BV / h, and the ethanol solutions with mass fractions of 35%, 55%, and 65% were eluted at 3.5BV each, and the flow rate of alcohol washing was 3.2BV / h, collect the eluate, after ...

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Abstract

The invention discloses a recombinant human insulin sustained-release tablet and a preparation method thereof. The recombinant human insulin sustained-release tablet is prepared from 8-12 weight parts of rhizoma anemarrhenae, 6-8 weight parts of radix astragali, 3-5 weight parts of camellia seed, 11-15 weight parts of recombinant human insulin, 22-30 weight parts of lecithin, 6-10 weight parts of cholesterol, 3-6 weight parts of collagen, 0.8-1.2 weight parts of vitamin E and 0.4-0.7 weight parts of chitosan. The preparation method comprises the following steps of pre-treating the raw materials and auxiliary materials, preparing freeze-dried powder of recombinant human insulin lipidosome, and carrying out tabletting molding. The recombinant human insulin sustained-release tablet is convenient for being taken by diabetics and has the characteristics of high encapsulation rate, good curative effect, safety, no toxicity and long action time.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a recombinant human insulin sustained-release tablet and a preparation method thereof. Background technique [0002] Diabetes (diabetes) is a sugar, protein, A series of metabolic disorder syndromes such as fat, water and electrolytes are clinically characterized by hyperglycemia, and typical cases may show polyuria, polydipsia, polyphagia, weight loss, etc., that is, "three more and one less" symptoms. Diabetic patients are unable to secrete insulin normally due to damaged islets and lack of function. Insufficient synthesis of insulin in the body leads to a significant decrease in the rate of fat synthesis and an increase in the rate of decomposition, which eventually leads to an increase in the content of free fatty acids in the blood. In the liver, mitochondria oxidize fatty acids to form triglycerides, and the deposition of triglycerides leads to the formation of fatty liver, or the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61K9/22A61P3/10A61K36/481A61K36/82A61K36/8964
Inventor 楼秀余
Owner 江西宇骏生物工程有限公司
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