Application of anthracene nucleus antibiotic and its pharmaceutical salt for treating ocular inflammation
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A technology of antibiotics and anthracyclines, applied in the field of drugs for the treatment of ocular inflammation, can solve problems such as inability to meet drug requirements, poor curative effect, and single indication
Inactive Publication Date: 2013-06-26
张雅珍
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Problems solved by technology
However, the current medicines for ocular inflammation are not only ineffective, but also often have a single indication. Clinically, the diagnosis of the disease or the testing of medicines often delay the best treatment time
And often many ocular inflammations will be secondary or concurrent to each other. The cornea and conjunctiva on the ocular surface, the retina and choroid of the fundus, and many exogenous and endogenous inflammations will be secondary or concurrent to each other. At present, many drug indications are It is relatively simple and cannot meet the requirements of medication. At present, it is necessary to develop a drug that has a very good therapeutic effect on most ocular inflammations, whether they occur on the ocular surface or in the eye, whether they come from exogenous or endogenous sources. , will save the diagnosis time, improve the therapeutic effect, not delay the treatment time, and minimize the damage of various eye inflammations to the eyes
Method used
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Embodiment 1
[0023] ① Take 300mg of poly(lactic-co-glycolic acid) (PLGA) and add it into 1ml of dichloromethane to prepare a solution;
[0024] ② Add 50 mg of arubicin to the solution prepared in ①, and stir with a high-speed homogenizer;
[0025] ③Use a syringe to slowly inject the solution in ② into the cottonseed oil containing 0.05% egg yolk oil, stir at 1000r / min for 20min, then reduce the speed to 200r / min and continue stirring for 4h;
[0026] ④Add 20ml petroleum ether to step ③, centrifuge at 8000r / min for 5min after 30min;
[0027] ⑤ Collect the microspheres, wash with petroleum ether and evaporate to dryness.
Embodiment 2
[0029] ① Take 200mg of poly(lactic-co-glycolic acid) (PLGA) and add it to 1ml of tetrahydrofuran solution to prepare a solution;
[0030] ② Add 50 mg of mitoxantrone to 0.2 ml of glycerin, mix well and add to the solution prepared in ①, stir with a homogenizer for 1 min to obtain colostrum;
[0031] ③Add it to 12ml of 2% polyvinyl alcohol (PVA) solution, stir at 1000r / min for 5min, then add 120ml of 0.5%PVA solution to obtain double emulsion;
[0032] ④ Reduce the rotational speed to 200r / min and continue stirring for 4h, then centrifuge at 8000r / min for 5min;
[0033] ⑤ The microspheres were collected, washed with distilled water and freeze-dried.
Embodiment 3
[0035] ① Take 100mg of polyanhydride-polyethylene glycol copolymer (PSA-PEG) and add it to 1ml of dichloromethane solution to prepare a solution;
[0036] ② Add 50mg of doxorubicin to the solution prepared in ①, and mix it by ultrasonic;
[0037] ③ Add the solution prepared in ② into 15ml 1% PVA solution;
[0038] ④ Reduce the rotational speed to 200r / min and continue stirring for 4h, then centrifuge at 8000r / min for 5min;
[0039] ⑤ Collect microspheres, wash with distilled water and collect.
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Abstract
The invention discloses an application of anthracene nucleus antibiotic and its pharmaceutical salt for treating ocular inflammation. The invention found that the anthracene nucleus antibiotic and its pharmaceutical salt have good effect on treatment of exogenous ocular inflammation and endogenous ocular inflammation, and especially the anthracene nucleus antibiotics can be prepared to prolonged action preparations such as a nano preparation, a microballoon preparation, liposome and hydrogel, the curative effect can be directly performed on ocular surface and eye ground, the toxicity of anthracene nucleus antibiotic is reduced, administration dosage is simultaneously enlarged through ophthalmic administration by prolonged action preparations, the duration time of drug effect is long, the medicament curative effect is stronger than that of the common preparations of the anthracene nucleus antibiotic, when the ophthalmic administration is carried out, the anthracene nucleus antibiotic has good treatment effect for exogenous and endogenous ocular surface, and eye ground inflammation, and especially has good treatment effect for the ocular surface and eye ground diseases caused by external wound, so that the problems of certain eyes inflammation with long treatment and more severe eye diseases due to eyes inflammation can be solved.
Description
technical field [0001] The present invention relates to a medicine for treating eye inflammation, in particular to the new application of a series of traditional antitumor antibiotics, that is, anthracycline antibiotics and pharmaceutically acceptable salts thereof in the preparation and treatment of eye inflammation, in particular, the anthracycline Antibiotics and pharmaceutically acceptable salts thereof are prepared into eye drops or long-acting preparations such as nanometer preparations, microsphere preparations, liposomes and hydrogels. Background technique [0002] Eye inflammation mainly refers to endophthalmitis, keratitis, conjunctivitis, iritis, retinitis, choroiditis, cyclitis, panuveitis, scleritis, optic neuritis, vitritis, lens inflammation, etc. Inflammation can be caused by exogenous and endogenous causes, such as exogenous causes such as mechanical injury, chemical injury, surgical trauma and secondary infection of some trauma, or autoimmune system disease...
Claims
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Application Information
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