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Bexarotene soft capsules and preparation method thereof

A technology of soft capsules and capsules, which is applied in the field of medicine, can solve the problems of expensive treatment costs, complicated drug regimens, and short duration, and achieve the effects of uniform dispersion of contents, improved drug stability, and easy absorption

Inactive Publication Date: 2013-07-03
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The incidence of cutaneous T-cell lymphoma in my country is increasing year by year. According to the particularity of the disease, direct skin radiotherapy or systemic combined chemotherapy is currently used, which has many side effects, low curative effect and short duration. Disadvantages such as complicated scheme and expensive treatment

Method used

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  • Bexarotene soft capsules and preparation method thereof
  • Bexarotene soft capsules and preparation method thereof
  • Bexarotene soft capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]

[0038] Preparation:

[0039] (1) chemical glue:

[0040] Capsule skin component: gelatin-glycerin-sorbitol-water-titanium dioxide (80:24:20:80:1);

[0041] Chemical glue process: first put a certain proportion of water into the chemical glue tank and heat it to 85°C, then put gelatin, glycerin, sorbitol, and titanium dioxide into the chemical glue tank in proportion and heat it to a suitable temperature, and fully stir for 30 to 60 minutes. Dissolve the material completely, remove air bubbles by vacuuming, and obtain the product.

[0042] (2) Preparation:

[0043] Process the bexarotene through a jet mill and set aside. Accurately weigh bexarotene, povidone K30, polysorbate 80, tert-butyl p-hydroxyanisole according to the prescription amount, add an appropriate amount of polyethylene glycol 400, grind and stir well to obtain the content of this product Suspension, spare. The suspension is transferred to the hopper of the pill making machine, the temperature of...

Embodiment 2

[0045]

[0046] The preparation method is the same as in Example 1.

Embodiment 3

[0048]

[0049] The preparation method is the same as in Example 1.

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Abstract

The invention discloses bexarotene soft capsules for treating cutaneous T-cell lymphoma and a preparation method thereof. The bexarotene soft capsules consist of bexarotene, polyethylene glycol 400, polysorbate 80, povidone K30 and butylated hydroxyanisole. The soft capsules can cover up bitterness of drug and discomfortable odor, make up the defects of other solid preparations and improve drug stability. Application of the single bexarotene soft capsules improves effectiveness, safety and medication compliance of clinical medication and greatly reduces toxic or side effects of combined medication.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a bexarotene soft capsule for treating skin T-cell lymphoma and a preparation method thereof. Background technique [0002] Bexarotene API chemical name: 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoic acid , is a kind of white, yellowish crystal, insoluble in water, slightly soluble in vegetable oil and ethanol. [0003] Bexarotene is a new type of synthetic retinoic acid analogue, which is used to treat refractory cutaneous T-cell lymphoma, which is relatively easy to cure in the early stage. As time goes by, the malignancy continues to increase and the cure is difficult. relatively increased. The incidence of cutaneous T-cell lymphoma in my country is increasing year by year. According to the particularity of the disease, direct skin radiotherapy or systemic combined chemotherapy is currently used, which has many side effects, low cur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/192A61K47/34A61P35/00
Inventor 张宁夏锦辉
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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