Multichannel printing electrode array chip as well as preparation method and application thereof

Abstract

The invention provides a multichannel printing electrode array chip comprising a substrate, an electrode unit array, a plurality of leads, a plurality of reverse side electrode contacts, and a cover plate, wherein the electrode unit array comprises a plurality of three-electrode systems arranged in a matrix manner, and each three-electrode system comprises a circular working electrode arranged on the upper surface of the substrate, and a cambered counter electrode and a cambered reference electrode which are symmetrically arranged on the two sides of the working electrode; the plurality of leads are in one-to-one correspondence with the working electrode, the counter electrode and the cambered reference electrode; the plurality of reverse side electrode contacts are connected with the leads in a one-to-one correspondence manner; and the cover plate is provided with circular holes in one-to-one correspondence with the three-electrode systems, wherein each circular hole is arranged in a manner of being corresponding to the corresponding three-electrode system to form a detecting pool. The multichannel printing electrode array chip disclosed by the invention is used for detecting samples, such as chemistry, biology and medicines, through using an electrochemical method, the device can be used for simultaneously analyzing and detecting multi-ingredient samples or different samples in groups clinically so as to obtain a plurality of data for one time, and the device has the advantages of high sensitivity, good selectivity, good stability, easiness for preparation, low cost and extensive adaption range, and the like.

Description

technical field [0001] The invention relates to the field of electrode array chip sensors, in particular to a multi-channel printed electrode array chip and its preparation method and application. Background technique [0002] Electrochemical sensor chip technology is a very fast-growing chemical and biological analysis method. At present, various chips are characterized by the parallel processing and high-density integration technology of microelectronics, and have the distinct advantages of high throughput, miniaturization, and intelligence. They have been used in disease diagnosis and prevention, drug screening, and gene expression. Remarkable achievements have been made in the fields of map analysis, gene fragment detection and peptide analysis. Electrochemical sensor chips have many unique advantages, such as high sensitivity, high precision, low price, and small size, which can realize portable on-site detection, can be easily fabricated into multi-element sensor arra...

AI Technical Summary

Problems solved by technology

[0003] Although the electrochemical detection methods at the present stage have broken through the limitation of single-channel detection, there is still room for progress in integration, because the existing multi-channel electrochemical array chips generally only use the form of a working electrode array as the detection channel, while Few integrated counter and reference electrodes together to form a three-electrode system

[0004] In addition, for the electrode array chip of the prior art, the continuous increase of the detection channel will become the bottleneck of its development, this is because: the planar electrode technology limits the area occupied by each electrode and its conductive path, increasing the channel is equal to reducing The area occupied by each electrode and its conductive path is small, and the result of this is the attenuation of the transmitted signal and the interference between different channels

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