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An antimicrobial composition

An antibacterial composition and composition technology, applied in the direction of drug combination, anti-infective drug, animal repellent, etc., can solve the problems of high toxicity of mammalian cells and achieve the effect of easy preparation

Active Publication Date: 2013-07-31
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Recent studies have managed to prepare quaternary ammonium or phosphorus functionalized polymers with excellent biocidal activity, however, these polymers have been shown to be highly toxic to mammalian cells

Method used

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Embodiment Construction

[0028] Illustrative, non-limiting embodiments of amphiphilic polymers according to the first aspect will now be disclosed.

[0029] In the disclosed antibacterial composition, the heterocyclic amine monomer unit may be selected from heterocyclic amines having 4-membered rings, 5-membered rings or 6-membered rings.

[0030] The heterocyclic amine monomer unit may be selected from the group consisting of azetidine, dihydroazete, pyrrolidine, imidazolidine, triazolidine, tetrazolidine, pentazolidine, pyrrole, imidazole , triazoles, pyridines, piperidines, diazinanes, triazinanes, pyrimidines, triazines, and combinations thereof.

[0031] Advantageously, nitrogen atoms located on the heterocycle are capable of forming bonds with hydrophobic linker groups to form extended polymeric or oligomeric structures. More advantageously, since the lone pair of free electrons becomes "depleted" in the formation of a covalent bond, the nitrogen atom can become electron deficient (or "electrop...

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Abstract

The present disclosure relates to an antimicrobial composition comprising at least one polymer or oligomer, the polymer and oligomer comprise repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer the antimicrobial activity to the composition, methods of producing the same and uses of the antimicrobial composition.

Description

technical field [0001] The present invention relates to antimicrobial compositions and the use of such compositions in biocidal, antibacterial and antifungal applications. Background technique [0002] Antibiotics were first isolated in 1939 and used to treat bacterial infections. For the past 70 years, antibiotics and other antimicrobial compounds have been at the forefront of the fight against infectious disease. However, long-term exposure to such compounds allows pathogens to evolve and develop resistance to different drugs and their mechanisms of action. Drug-resistant pathogens have been found in an increasing number of bacterial species, and pathogens resistant to multiple drug types have also been identified in the medical community. In the current environment, clinicians and researchers face increasing difficulties in developing suitable antibiotics that target pathogens with novel mechanisms of action that are not hampered by resistance developed by other The pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N33/02
CPCA01N33/02C08G61/123A01N43/50C08G2261/3221C08L79/04C08G73/0616A61K31/787C07D403/14C08F12/26C07D233/61A61P31/00Y02A50/30A01N25/10A01N25/34A01N2300/00
Inventor 张玉根刘利红
Owner AGENCY FOR SCI TECH & RES
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