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Micro-/nano- structure filler-based solid phase extractor

A micro-nano structure, solid-phase extraction column technology, applied in chemical instruments and methods, solid adsorbent liquid separation, separation methods, etc. The effect of column bed volume, reduced usage, and improved efficiency

Active Publication Date: 2013-08-28
苏州东奇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the small amount of small-sized micron adsorbents and nano-adsorbents and the small amount of rinsing and eluting solutions, if small-sized adsorbents are used, conventional solid-phase extraction columns for constant packing will no longer applicable

Method used

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  • Micro-/nano- structure filler-based solid phase extractor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: nanofiber adsorbent

[0020] Fill 5 mg of nanofibers into the adsorbent filling part 2, add a small amount of activation solution into the small volume solution storage part 4, pull out the push rod 13 of the positive pressure column passing device, and connect the connecting head 9 is connected with the solid phase extraction column, pushes the push rod 13 to make the solution in the solid phase extraction column flow out slowly from the lower outlet.

[0021] Pull out the positive pressure column passing device and push rod 13, add the sample solution to be processed into the solid phase extraction column, and make the solution flow out slowly from the outlet below in the above-mentioned manner, at this time, the target substance is adsorbed on the nanofiber.

[0022] A small amount of eluent is added to the small-volume solution storage part 4, and the eluent flows out from the lower outlet in the above-mentioned manner to wash away the impurities adsor...

Embodiment 2

[0024] Example 2: Small-sized micron-sized particle adsorbent

[0025] Put the small sieve plate under the adsorbent filling part 2, fill 50 mg of adsorbent in the adsorbent filling part 2 and the small volume solution storage part 4, fix the adsorbent with a sieve plate above, and use an appropriate amount of activation solution , eluent and eluent, and process the sample according to the above process.

Embodiment 3

[0026] Embodiment 3: sample processing of negative pressure type and large sample volume

[0027] Fill the appropriate amount of adsorbent in the solid-phase extraction column, add the activation solution to the solid-phase extraction column, install the adsorbent filling part 2 of the solid-phase extraction column on a commercial solid-phase extraction instrument, start the vacuum pump, Let the activation solution flow out from the outlet below.

[0028] Connect the connection head 9 under the pressure tube 11 to the solid phase extraction column, add the sample solution, and let the sample solution flow out in the above-mentioned manner.

[0029] Add the eluent into the pressurized tube 11 and the solid-phase extraction column, and let the eluent flow out in the above-mentioned manner.

[0030] Remove the pressurizing tube 11, add eluent to the solid phase extraction column, let the eluent flow out and collect the eluent in the above-mentioned manner, and take an appropriat...

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Abstract

The invention provides a micro- / nano- structure filler-based solid phase extractor. The micro- / nano- structure filler-based solid phase extractor comprises 1, a solid phase extraction column which is an all-in-one pipe and orderly comprises a sample storage unit (6), a small-volume solution storage unit (4) and an adsorbent filling unit (2) from top to bottom, and 2, a positive-pressure column chromatography device which is located above the solid phase extraction column and comprises a compression pipe (11) and a push rod (13), wherein an inner diameter of the compression pipe (11) matches with an outer diameter of the push rod (13); an upper end opening (7) of the sample storage unit (6) is sleeved on a joint (9) at a lower end opening of the compression pipe (11); and the push rod (13) downward presses air in the compression pipe (11) along an inner wall of the compression pipe (11) to push a sample in the sample storage unit (6) so that the sample flows through the adsorbent filling unit (2) and thus extraction is realized. The micro- / nano- structure filler-based solid phase extractor can realize different filled volumes of different adsorbents, can effectively reduce an adsorbent column bed volume and can improve sample pre-treatment efficiency.

Description

technical field [0001] The invention relates to a solid-phase extractor based on a micro-nano structure filler, in particular to a solid-phase extraction device suitable for small-sized adsorbents. Background technique [0002] The analytical objects faced by modern separation and analysis techniques are becoming more and more complex and the content of the analytical objects is becoming less and less. Sample pretreatment technology is particularly important in sample analysis. At present, solid phase extraction is mostly used for sample pretreatment. This technology has the characteristics of less organic solvent consumption, safe and efficient, and convenient batch processing of samples. [0003] Facing the extraction of increasingly complex samples, the size of the adsorbent materials used in solid-phase extraction is developing from small micron to nano-scale to improve the efficiency of solid-phase extraction columns. Usually, the size of micron-sized adsorbents is mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/10B01D15/20
Inventor 邓剑军
Owner 苏州东奇生物科技有限公司