Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Artificial bone material and preparation method thereof

A technology of artificial bone and raw materials, applied in the field of materials, can solve problems such as low porosity, poor pore traffic performance, and insufficient mechanical strength, and achieve the effects of low printing temperature, good formability, and low melting point

Active Publication Date: 2014-11-05
珠海市红旌发展有限公司
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, judging from the current production process and products, the prepared hydroxyapatite / collagen composites still have shortcomings such as insufficient mechanical strength, low porosity, and poor pore traffic performance.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Artificial bone material and preparation method thereof
  • Artificial bone material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] figure 1 Show the preparation method of artificial bone material according to one embodiment of the present invention, as shown in the figure:

[0032] First enter step S1100 to prepare collagen PO 4 3- Solution: Prepare 450ml of collagen aqueous solution with a concentration of 0.1%, add 0.1mol / l H 3 PO 4 30ml of the solution was dropped into the aqueous collagen solution and stirred for 20 minutes. Then enter step S1200 to prepare collagen / nanocellulose composite solution: the preparation concentration is 1ml of nanocellulose aqueous solution of 5%, and the collagen PO prepared in step S1100 4 3- The solution is blended and stirred, and then homogenized by a high-pressure homogenizer. Finally enter step S1300 to prepare collagen / hydroxyapatite / nanocellulose composite material: prepare CaCl with a concentration of 0.2mol / l 2 Solution 25ml, drop into the collagen / nanocellulose homogeneous solution, set the Ca / P molar ratio to 1.67, and stir for 1.5h to ensure tha...

Embodiment 2

[0034] figure 1 Show the preparation method of artificial bone material according to one embodiment of the present invention, as shown in the figure:

[0035] First enter step S1100 to prepare collagen PO 4 3- Solution: prepare 1ml of 10% collagen aqueous solution, mix 0.5mol / l (NH 4 ) 2 HPO 4 7ml of the solution was dropped into the aqueous collagen solution and stirred for 30 minutes. Then enter step S1200 to prepare collagen / nanocellulose composite solution: preparation concentration is 20ml of nanocellulose aqueous solution of 0.5%, mix it with the collagen PO prepared in step S1100 4 3- The solution is blended and stirred, and then homogenized by a high-pressure homogenizer. Finally enter step S1300 to prepare collagen / hydroxyapatite / nanocellulose composite material: prepare Ca(OH) with a concentration of 0.6mol / l 2 10ml of the solution was dropped into the collagen / nanocellulose homogeneous solution, neutralized with sodium hydroxide to pH 8, the Ca / P molar ratio...

Embodiment 3

[0037] figure 1 Show the preparation method of artificial bone material according to one embodiment of the present invention, as shown in the figure:

[0038] First enter step S1100 to prepare collagen PO 4 3- Solution: prepare 41ml of 1% collagen aqueous solution, add 0.3mol / l Na 2 HPO 4 14ml of the solution was dropped into the aqueous collagen solution and stirred for 30 minutes. Then enter step S1200 to prepare collagen / nanocellulose composite solution: prepare 2ml of nanocellulose aqueous solution with a concentration of 0.5%, and mix it with the collagen PO prepared in step S1100 4 3- The solution is blended and stirred, and then homogenized by a high-pressure homogenizer. Finally enter step S1300 to prepare collagen / hydroxyapatite / nanocellulose composite material: the preparation concentration is 0.8mol / l Ca(NO 3 ) 2 7ml of the solution was dropped into the collagen / nanocellulose homogeneous solution, the Ca / P molar ratio was set to 1.67, and stirred for 2h to e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of an artificial bone material. The preparation method comprises providing raw materials including hydroxyapatite, collagen and nano-crystalline cellulose. The preparation method comprises: step (S1100). dropping a solution containing PO4<3-> of 0.05-0.5 mol / L into a collagen solution with a mass percent concentration of 0.1-1%, stirring to keep in reserve; step (S1200). preparing a nano-crystalline cellulose solution with a mass percent concentration of 0.5-10%, and mixing the nano-crystalline cellulose solution and the collagen PO4<3-> solution prepared by the step (S1100), stirring and homogenizing; step (S1300). adding a solution containing Ca<2+> of 0.2-0.8 mol / L into the collgen / nano-crystalline cellulose composite solution prepared by the step (S1200), setting the mol ratio of Ca to P as 1.67, adjusting the pH to 7-9 with an alkaline solution and precipitating, freeze-drying the precipitation to obtain the artificial bone material.

Description

technical field [0001] The invention relates to a material, in particular to an artificial bone material and a preparation method thereof. Background technique [0002] Bone tissue is composed of organic components and inorganic components. In adult bone, the organic components account for about 1 / 3, and the inorganic components account for about 2 / 3. Collagen accounts for about 95% of the organic components, while the inorganic components are mainly hydroxyapatite. Therefore, it can be said that natural bone is composed of low crystallinity hydroxyapatite and collagen. [0003] Synthetic hydroxyapatite has good biocompatibility and bioactivity, it is an excellent hard tissue replacement material, and because the grains of hydroxyapatite have surface effect and volume effect, after implanted in the human body It can bond with human tissue through hydrogen bonds to achieve perfect affinity, has no immune rejection phenomenon and has certain bone conduction properties. It ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46
Inventor 蓝海时圣涛任方萍黎国康
Owner 珠海市红旌发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com