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Method for extracting evoked potentials under high stimulation ratio

A technology of evoked potential and stimulation sequence, which is applied in the field of biomedical signal processing, can solve problems such as the inability to achieve stable and accurate extraction and restoration of transient evoked potential, limit the clinical research and application of high stimulation rate technology, and achieve accuracy and stability Effect of extracting and restoring, reducing the impact of signal restoration

Inactive Publication Date: 2013-10-09
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the existing technology cannot control the influence of noise interference, and cannot achieve stable and accurate extraction and recovery of transient evoked potentials, which limits the clinical research and application of high stimulation rate technology

Method used

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  • Method for extracting evoked potentials under high stimulation ratio
  • Method for extracting evoked potentials under high stimulation ratio
  • Method for extracting evoked potentials under high stimulation ratio

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Combining simulation calculation to illustrate how the present invention extracts transient AEP (auditory evoked potential)

[0050] A stimulus generator capable of outputting stimuli with high time accuracy according to a custom stimulus sequence and recording the stimulus output time information at the same time. The EEG acquisition system can be a conventional system that meets the specifications.

[0051] (1) Electrode placement: According to the conventional AEP recording method, the recording electrode is placed on the hairline of the forehead of the subject, the reference electrode is placed on the ipsilateral mastoid, and the ground electrode is placed on the center of the brow. The electrode impedance is less than 5KΩ.

[0052] (2) Stimulus output: First, the stimulus sequence meets the following conditions:

[0053] The stimulus sequence uses a periodic pulse train signal with a period of T, and its expression is:

[0054] s T ( t ) = X ...

Embodiment 2

[0076] Example 2: To illustrate the effect of the present invention by comparing with existing methods

[0077] Use an optimized stimulus sequence obtained in the sense of continuous time, such as figure 2 As shown in (a), the stimulation sequence includes 13 stimulation pulses, and the time when the stimulation pulse appears t i = {0, 110.6, 248.2, 363.2, 478.6, 614.8, 735.8, 867.1, 1006.5, 1130.1, 1240.7, 1351.3, 1490.8} ms, the length of the sequence is T = 1625.8 ms, the selected frequency band range [f L , F H ] Inverse of the spectrum|S c (kf 0 ) -1 |Such as figure 2 (d) Shown.

[0078] In order to explain the error caused by the extraction of transient evoked potentials through discrete Fourier transform in the prior art, we choose 10 sampling rates to convert the sequence into discrete sequences, and the specific sampling rates are {1,2,3,4,5 , 7, 9, 11, 15, 20}kHz. The discrete sequence at a sampling rate of 20kHz is like figure 2 (c) shows that t i 'Represents the posi...

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Abstract

The invention discloses a method for extracting evoked potentials under a high stimulation ratio. The method includes the steps of firstly, repeatedly outputting a stimulation sequence with vibration, sampling brain electrical signals of a testee under repeated stimulation of the stimulation sequence, and obtaining observation signals; secondly, conducting superposition average calculation on the observation signals, restraining random noise in the observation signals, and obtaining an average observation signal; thirdly, conducting fast Fourier transform on the average observation signal to obtain a frequency domain signal of the average observation signal, and calculating continuous cycle Fourier transform of the stimulation sequence to obtain a frequency domain signal of the stimulation sequence; fourthly, conducting calculation to obtain a frequency domain signal of a transient-state evoked potential; fifthly, conducting Fourier inversion to obtain a transient-state evoked potential signal in a time domain form. According to the method for extracting the evoked potentials under the high stimulation ratio, the influence of noise interference components on signal recovery is greatly reduced, and the transient-state evoked potentials can be accurately and stably extracted and recovered. The method for extracting the evoked potentials under the high stimulation ratio can be widely applied to the biomedical field.

Description

Technical field [0001] The invention relates to the field of biomedical signal processing, in particular to a method for extracting transient evoked potentials under high stimulation rates by using continuous Fourier transform. Background technique [0002] Evoked potential (EP) is a comprehensive response of the brain to the electrical activity of external stimuli. Evoked potentials are of great significance in many disciplines such as clinical medicine, electrophysiology, psychology and cognitive science. At present, evoked potentials are mainly divided into three modes according to different stimulation methods: Auditory Evoked Potential (AEP), Visual Evoked Potential (VEP) and Somatosensory Evoked Potential (SEP). In addition, methods for obtaining evoked responses using magnetic, laser and other stimuli are also constantly being developed. [0003] Taking auditory transient stimuli as an example, the click sound (typical duration 0.1ms) used on the auditory system can induce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0476
Inventor 林霖王涛黄江华
Owner SOUTHERN MEDICAL UNIVERSITY
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