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Method for extracting evoked potentials under high stimulation ratio

A technology of evoked potential and stimulation sequence, which is applied in the field of biomedical signal processing, can solve problems such as the inability to achieve stable and accurate extraction and restoration of transient evoked potential, limit the clinical research and application of high stimulation rate technology, and achieve accuracy and stability Effect of extracting and restoring, reducing the impact of signal restoration

Inactive Publication Date: 2015-03-11
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology

Therefore, the existing technology cannot control the influence of noise interference, and cannot achieve stable and accurate extraction and recovery of transient evoked potentials, which limits the clinical research and application of high stimulation rate technology

Method used

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  • Method for extracting evoked potentials under high stimulation ratio
  • Method for extracting evoked potentials under high stimulation ratio
  • Method for extracting evoked potentials under high stimulation ratio

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: how the present invention extracts transient AEP (auditory evoked potential) is illustrated in conjunction with simulation calculation

[0050] A stimulus generator capable of outputting stimulus sounds with high time precision according to a custom stimulus sequence and simultaneously recording the stimulus output time information is used. The EEG acquisition system can adopt a conventional system that meets the specifications.

[0051] (1) Electrode placement: According to the conventional AEP recording method, the recording electrode was placed at the hairline in the middle of the forehead of the subject, the reference electrode was placed at the mastoid on the same side, and the ground electrode was placed at the center of the eyebrows. The electrode impedance was less than 5KΩ.

[0052] (2) Stimulus sound output: First, the stimulus sequence meets the following conditions:

[0053] The stimulation sequence adopts a periodic pulse train signal with pe...

Embodiment 2

[0076] Embodiment 2: the effect of the present invention is illustrated by comparing with existing methods

[0077] Using an optimized sequence of stimuli obtained in a continuous time sense, such as figure 2 As shown in (a), the stimulation sequence includes 13 stimulation pulses, and the time t of the stimulation pulse appears i ={0, 110.6, 248.2, 363.2, 478.6, 614.8, 735.8, 867.1, 1006.5, 1130.1, 1240.7, 1351.3, 1490.8}ms, the length of the sequence is T=1625.8ms, the selected frequency band range [f L , f H ]The number of cases of spectrum in ]|S c (kf 0 ) -1 |such as figure 2 (d) shown.

[0078] In order to illustrate the error caused by the extraction of transient evoked potentials by discrete Fourier transform in the existing technology, we choose 10 sampling rates to convert the sequences into discrete sequences, and the specific sampling rates are {1, 2, 3, 4, 5 , 7, 9, 11, 15, 20} kHz. The discrete sequence when the sampling rate is 20kHz is as follows fi...

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Abstract

The invention discloses a method for extracting evoked potentials under a high stimulation ratio. The method includes the steps of firstly, repeatedly outputting a stimulation sequence with vibration, sampling brain electrical signals of a testee under repeated stimulation of the stimulation sequence, and obtaining observation signals; secondly, conducting superposition average calculation on the observation signals, restraining random noise in the observation signals, and obtaining an average observation signal; thirdly, conducting fast Fourier transform on the average observation signal to obtain a frequency domain signal of the average observation signal, and calculating continuous cycle Fourier transform of the stimulation sequence to obtain a frequency domain signal of the stimulation sequence; fourthly, conducting calculation to obtain a frequency domain signal of a transient-state evoked potential; fifthly, conducting Fourier inversion to obtain a transient-state evoked potential signal in a time domain form. According to the method for extracting the evoked potentials under the high stimulation ratio, the influence of noise interference components on signal recovery is greatly reduced, and the transient-state evoked potentials can be accurately and stably extracted and recovered. The method for extracting the evoked potentials under the high stimulation ratio can be widely applied to the biomedical field.

Description

technical field [0001] The invention relates to the field of biomedical signal processing, in particular to a method for extracting transient evoked potentials at high stimulation rates by continuous Fourier transform. Background technique [0002] Evoked potential (EP) is the comprehensive response of the brain to the electrical activity of external stimuli. Evoked potentials are of great importance in several disciplines including clinical medicine, electrophysiology, psychology, and cognitive science. At present, evoked potentials are mainly divided into three modes according to different stimulation methods: Auditory Evoked Potential (AEP), Visual Evoked Potential (VEP) and Somatosensory Evoked Potential (SEP). In addition, methods of obtaining evoked responses using other stimuli such as magnetism and laser are also being developed. [0003] Taking auditory transient stimulation as an example, the click sound (typical duration 0.1 ms) stimulation to the auditory syste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/0476
Inventor 林霖王涛黄江华
Owner SOUTHERN MEDICAL UNIVERSITY
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