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Chitosan sponge surgical dressing and preparation method thereof

A technology of chitosan and carboxymethyl chitosan, applied in medical science, bandages, absorbent pads, etc., can solve problems such as poor adsorption capacity, easy to become hard and brittle, unstable, etc., to achieve improved liquid absorption capacity, The effect of long-lasting adsorption capacity and excellent softness

Active Publication Date: 2014-05-07
JIANGSU DIWO BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there are also documents disclosing the application of chitosan derivatives, such as: Chinese patent CN 200510024503 discloses a carboxymethyl chitosan sponge with water-absorbing swelling properties. Carboxymethyl chitosan aqueous solution of polysaccharide, chitosan powder or chitin powder, glycerin plasticizer and environment-friendly ion crosslinking agent is used to prepare sponge, but in this technical scheme, sponge is because foaming is not enough, and hole is few and Unstable, easy to harden, poor adsorption capacity, and easy to become hard and brittle during use; the Chinese application patent application number 20110136324.4 discloses a hemostatic sponge, which is obtained by compounding molecular sieves and chitosan. Better hemostatic properties of chitosan
However, the above-mentioned technical scheme only starts from the biocompatibility and biodegradability of chitosan, and does not take into account the adsorption performance and soft plasticity of medical biological dressings when they are used.

Method used

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  • Chitosan sponge surgical dressing and preparation method thereof
  • Chitosan sponge surgical dressing and preparation method thereof
  • Chitosan sponge surgical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment one: a kind of chitosan sponge body medical dressing, specifically medical sponge, it comprises the component of following mass percentage: 2% carboxymethyl chitosan, 1% poloxamer, 2% poly ethylene glycol. The preparation method is as follows: add the poloxamer to purified water and soak for 1 hour; then use a stainless steel stirrer to stir the soaked poloxamer twice at a low speed of 100 r / min, and then reduce the speed to 100 r / min. Stir twice at a low speed of 180 r / min; after the poloxamer is completely dissolved, add polyethylene glycol to the solution, stir three times at a medium speed of 300 r / min until the solution is uniform, and then add to the solution while stirring Carboxymethyl chitosan is dissolved evenly to prepare foaming liquid, and then the stainless steel stirrer is stirred at a high speed of 700r / min. When the volume of the foaming liquid expands to 4-5 times of the original, the foaming liquid is injected into the silica gel In the mo...

Embodiment 2

[0048] Embodiment two: a kind of chitosan sponge body medical dressing, specifically medical sponge, it comprises the component of following mass percent: 7% carboxymethyl chitosan, 2% poloxamer, 5% poly ethylene glycol. The preparation method is as follows: add the poloxamer to purified water and soak for 3 hours; then stir the soaked poloxamer at a speed of 150 r / min with a stainless steel stirrer; wait until the poloxamer is completely dissolved Afterwards, polyethylene glycol was added to the solution ， Stir at a speed of 400 r / min until the solution is uniform, then add carboxymethyl chitosan to the solution while stirring until it dissolves evenly to obtain a foaming liquid, then stir at a speed of 700 r / min, and wait for foaming When the volume of the liquid expands to 4-5 times of the original, pour the foaming liquid into the silicone mold tray, put it into the quick-freezing box as soon as possible, and let it be pre-frozen for 5 hours; Put it into a vacuum freeze ...

Embodiment 3

[0049] Embodiment three: a chitosan sponge medical dressing, specifically a medical sponge, which includes the following components by mass percentage: 3.5% carboxymethyl chitosan, 1% poloxamer, 2.5% poly ethylene glycol. The preparation method is as follows: add the poloxamer to purified water and soak for 3 hours; then use a stainless steel stirrer to stir the soaked poloxamer at a speed of 180 r / min; wait until the poloxamer is completely dissolved Afterwards, polyethylene glycol was added to the solution ， Stir at a speed of 300 r / min until the solution is uniform, then add carboxymethyl chitosan to the solution while stirring until it dissolves evenly to obtain a foaming liquid, then stir at a speed of 600 r / min, and wait for foaming When the volume of the liquid expands to 4-5 times of the original, pour the foaming liquid into the silicone mold tray, put it into the quick-freezing box as soon as possible, and make it pre-freeze for 15 hours; Put it into the vacuum fre...

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Abstract

The invention discloses a chitosan sponge surgical dressing and a preparation method thereof. The chitosan sponge surgical dressing includes, by mass, 0.1% to 10% of water-soluble chitosan or a salt thereof, 0.001% to 5% of a foaming agent and 0.05% to 8% of a humectant. The chitosan sponge surgical dressing provided by the invention has a good foaming effect, high adsorption capacity, powerful moisture retention, softness and good plasticity and fills a gap in excellent surgical dressings.

Description

technical field [0001] The invention relates to the cross-linking technology of tissue engineering support materials, in particular to a chitosan sponge medical dressing and a preparation method thereof. Background technique [0002] A dressing is a medical material used to temporarily cover a wound. Its main function is to control the exudate of the wound and protect the wound from contamination by bacteria and dust particles, providing an environment conducive to wound healing. Choosing the right dressing to cover a wound can help control bleeding, prevent infection, and absorb secretions, thereby promoting rapid wound healing. At this time, the dressing can protect the wound surface, prevent the loss of body fluid and protein, prevent bacterial invasion and cause inflammation, and provide support for proliferating cells. Skin trauma is a common clinical disease. When there is a large area of ​​skin defect or it is difficult to heal in a short time, it is extremely import...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42C08J9/28
Inventor 贾峻峰
Owner JIANGSU DIWO BIOLOGICAL PROD
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