Methods of metabolic targeting cancer cells using che mo- and immunotherapy for treating cancer
An immunotherapy, cancer cell technology, applied in chemical instruments and methods, metabolic diseases, immunoglobulins, etc., can solve problems such as exhaustion, interference, long-term immunosuppression, etc.
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Embodiment 1
[0130] Example 1: Metabolic Targeted Chemotherapy Has Beneficial Clinical Effects
[0131] patient. Six patients with several metabolically advanced cancers (i.e. stage IIIB / IV) that had not previously responded to standard treatment with one or more chemotherapeutic agents, radiation, surgery, or other forms of treatment were selected and performed as follows treat.
[0132] treatment solutions. Before treatment, patients were imaged by computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), or a combination thereof, and baseline tumor mass was calculated. On Day 0, patients are fasted overnight to achieve baseline glucose levels (typically about 4.5-5.5 mmol / L). The next day (Day 1), after an initial IV infusion with 500 cc of saline, all patients received insulin (Humalog) intravenously (i.v.) at a dose of 0.1 to 0.5 units / kg body weight to lower blood glucose levels to baseline About half of the level (about 2.2-2.8mmol / L). ...
Embodiment 2
[0144] Example 2: Metabolic Targeted Chemoimmunotherapy for the Treatment of Cancer
[0145] patient. Select patients with several metabolically advanced cancers (i.e., stage IIIB / IV; cancer types are shown in Table 4 below) that have not previously responded to standard treatment with one or more chemotherapeutic agents, radiation, surgery, or other forms of treatment Patients who were treated at No. 383 Changying East Road, Xi'an Xincheng Borui Hospital and Yangling Demonstration Area Hospital were treated as described below.
[0146] treatment solutions. Before treatment, patients were imaged by computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), or a combination thereof, and baseline tumor mass was calculated.
[0147] On day 0, the patient is administered an immunizing agent such as a therapeutic antibody or functional fragment thereof. Therapeutic antibodies that may be used in this treatment regimen may include commerci...
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