Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Sarcaboside B in preparation of medicines for treating atherosclerosis

An atherosclerosis and drug technology, applied in the application field of Sarcaboside B in the treatment of atherosclerosis drugs, can solve the problems such as the cause and pathogenesis have not been fully elucidated, and there are no preventive measures and therapeutic drugs.

Inactive Publication Date: 2013-10-23
丁圣雨
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective preventive measures and therapeutic drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Sarcaboside B in preparation of medicines for treating atherosclerosis
  • Application of Sarcaboside B in preparation of medicines for treating atherosclerosis
  • Application of Sarcaboside B in preparation of medicines for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Sarcaboside B tablet involved in the present invention:

[0013] Take 20 grams of compound Sarcaboside B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Sarcaboside B capsules involved in the present invention:

[0015] Get 20 grams of compound Sarcaboside B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] The present invention reveals the effect of Sarcaboside B on atherosclerosis through cell level research and establishment of atherosclerosis model.

[0018] Oral and intravenous administration of Sarcaboside B in the present invention can significantly reduce plaque area / intima area (%), intima thickness (um) / media thickness (%) in atherosclerotic rats; Triesters, total cholesterol and low-density lipoprotein levels decreased, indicating that Sarcaboside B can treat atherosclerosis.

[0019] Materials and Methods

[0020] 1. Experimental materials:

[0021] 1.1 Animals and fee...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of Sarcaboside B in the preparation of medicines for treating atherosclerosis. The Sarcaboside B can play a role in resisting the atherosclerosis by regulating blood lipids and protecting endothelial cells. The medicines for resisting the atherosclerosis, prepared from the Sarcaboside B, have relatively good curative effects on the atherosclerosis and can be used for resisting the atherosclerosis of people or animals. The application of the Sarcaboside B in the preparation of the medicines for treating the atherosclerosis is disclosed by the invention for the first time. As the skeleton type of the Sarcaboside B belongs to a brand-new skeleton type, the Sarcaboside B has unexpected strong inhibitory activity on the atherosclerosis, and the possibility that other compounds provide revelation does not exist. The Sarcaboside B has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for resisting the atherosclerosis.

Description

technical field [0001] The invention relates to the application of Sarcaboside B in the preparation of medicines for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. [0003] The compound Sarcaboside B involved in the present invention is a new skeleton compound published in 2012 (Li, X. et al., 2012. Two New-Skeleton Compounds from Sarcandra glabra. Helvetica Chimica Acta 95 (6), 998-1002.), This compound has a brand-new skeleton type, and there is no report about its activity at present. The use of S...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/365A61P9/10
Inventor 丁圣雨
Owner 丁圣雨
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com