Extraction agent for synchronous production of various functional components of cape jasmine, and extraction and separation method thereof

A technology of simultaneous extraction and extraction agent, applied in medical preparations containing active ingredients, solid solvent extraction, chemical instruments and methods, etc., to reduce production costs, reduce energy and solvent consumption, and reduce extraction production cycle time.

Active Publication Date: 2013-10-23
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no process technology that integrates online membrane separation and dual-column series resin column chromatography purification to simultaneously produce extraction and separation preparation methods for various functional components of gardenia

Method used

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  • Extraction agent for synchronous production of various functional components of cape jasmine, and extraction and separation method thereof
  • Extraction agent for synchronous production of various functional components of cape jasmine, and extraction and separation method thereof
  • Extraction agent for synchronous production of various functional components of cape jasmine, and extraction and separation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Components and ratio of extractant (calculated by weight): metaphosphoric acid 0.03kg, Tween-800.03kg, tap water 50kg.

[0066] Take 4 kg of dried gardenia fruit, put it into the extraction tank, add 60 kg of extractant, cover and seal it to control the temperature at 50 ° C, stir intermittently for 5 minutes every hour, and after leaching for 6 hours, filter out the filtrate, and then add 20 kg of extractant to carry out For the second extraction in 4 hours, the two extracts were combined and 74kg was filtered out after coarse filtration by a centrifuge, and cooled to 25°C; The column removes the hydrophilic components, and this part of the eluate is fractionated and concentrated by microfiltration membrane, ultrafiltration, reverse osmosis membrane, and then vacuum-dried at low temperature or freeze-dried to obtain 0.5kg of gardenia pectin polysaccharide component; then use 25% ethanol Elution and elution with 70% ethanol, collect the eluent respectively, concentrate ...

Embodiment 2

[0069] Components and ratio of extractant (calculated by weight): sodium metaphosphate 0.5kg, sodium fatty acid methyl ester sulfonate 0.5kg, tap water 450kg.

[0070] Take 50kg of dried gardenia fruit and 500kg of extractant, put them into an extraction tank, control the temperature at 55°C, stir intermittently for 15 minutes per hour, after leaching for 6 hours, filter out the filtrate, and use 200kg of extractant for another 5 hours for the second extraction. For secondary extraction, the two extracts were combined and then filtered. After 650 kg of filtrate was cooled, it flowed through the HPD300 resin adsorption column for 4 hours. After the column was washed with 850 kg of deionized water successively, it was eluted with 25% ethanol and 80% ethanol respectively. The water eluate flows through the microfiltration membrane to filter and remove impurities, and then is fractionated and concentrated by ultrafiltration and reverse osmosis membrane to obtain the concentrated so...

Embodiment 3

[0073] Components and ratio of extractant (calculated by weight): metaphosphoric acid 0.2kg, sodium fatty acid methyl ester sulfonate 0.2kg, tap water 250kg.

[0074] Take 20kg of dried gardenia fruit and 250kg of extractant, put them into an extraction tank, control the temperature at 60°C, stir intermittently for 15 minutes per hour, after leaching for 5 hours, filter out the filtrate, and use 160kg of extractant for another 5 hours of extraction. For the second extraction, the two extracts were combined and then filtered. 400kg of the filtrate was cooled and passed through the HPD300 resin adsorption column. Filtration and reverse osmosis membrane fractional concentration to obtain a concentrated solution of gardenia polysaccharides, which was vacuum-dried at low temperature or freeze-dried to obtain 2.5 kg of gardenia pectin polysaccharide components; and then eluted with 20% ethanol and 65% ethanol respectively. The ethanol eluate was concentrated by vacuum rotary evapora...

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Abstract

The invention specifically relates to a high-efficient extraction agent for synchronous extraction of four effective functional components from cape jasmine fruits, and an extraction, separation and purification process. The key of the invention is to innovate a new extraction agent, and a water extraction technology containing a certain of stabilizer and / or cosolvent is adopted for replacing a percolation extraction or alcohol extraction process which is commonly used in the current production process, so that the production period is greatly reduced and the production and processing cost is effectively lowered; and the invention further comprises a process technology integrating online membrane separation and concentration with double-column tandem column chromatography for purification and integration, which can realize high-efficient preparation of various functional components from cape jasmine. The extraction agent disclosed by the invention has the advantages of low cost, small using quantity and no residues, and can obviously improve the dissolution rate of terpenoid and phenol compounds in raw materials of the cape jasmine fruits and enable the product extraction rate to exceed 95%; and the method is also suitable for extraction, separation and preparation of the functional components in other parts of the raw materials in addition to the cape jasmine fruits.

Description

technical field [0001] The invention belongs to the technical field of natural product extraction, and relates to a high-efficiency extractant and water extraction method for synchronously producing a variety of gardenia functional components using gardenia as a raw material, and includes fusion on-line membrane separation and concentration and double-column series column chromatography purification Integrated process technology to prepare four types of high-purity gardenia effective functional components. Background technique [0002] Gardenia is widely distributed in China and is rich in resources. It can be used for both medicine and food. It belongs to the first batch of medicine and food resources promulgated by the Ministry of Health. Gardeniae has the functions of purging fire and relieving restlessness, clearing heat and diuresis, cooling blood and detoxifying. It is used for fever, upset, jaundice, red urine, red eyes, swelling and pain, and external treatment of sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02C08B37/08C09B61/00A61K36/744
Inventor 何静仁段李歌蔡小双
Owner WUHAN POLYTECHNIC UNIVERSITY
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