A kind of nano-chitosan artemisinin complex and preparation method thereof

A technology of nano-chitosan and artemisinin derivatives is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations of inactive ingredients, etc., which can solve the problems of poor water solubility and low bioavailability of artemisinin, and achieve easy The effect of human body absorption, treatment application improvement, and bioavailability improvement

Active Publication Date: 2016-02-10
四川绵阳四〇四医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the poor water solubility of artemisinin in the prior art, low bioavailability, and easy to produce drug resistance, and provide a nano-chitosan artemisinin complex

Method used

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  • A kind of nano-chitosan artemisinin complex and preparation method thereof
  • A kind of nano-chitosan artemisinin complex and preparation method thereof
  • A kind of nano-chitosan artemisinin complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Get 0.56g nano-chitosan and be dissolved in 100ml water, be mixed with 0.56% nano-chitosan sol. Take 10mL of nano-chitosan sol (gifted by Guanghan Hengyu New Material Co., Ltd., the same below), add 2mg of povidone K30 (that is, medical grade PVP-K30), stir well, adjust the temperature to 80°C, and add 42mg of dihydrogen The artemisinin was stirred for 0.5 h at a rotational speed of 1000 r / min to obtain a uniformly dispersed nano-chitosan dihydroartemisinin sol, and dried at 70° C. to obtain a nano-chitosan dihydroartemisinin complex powder.

Embodiment 2

[0043] Take 9mL of the nano-chitosan sol prepared in Example 1, add 2.6mg of povidone K60 (that is, medical grade PVP-K60), and fully stir until the solution is clear and transparent, adjust the temperature to 50°C, and add 47mg of artemether , stirred at 600 r / min for 3 hours to obtain a uniformly dispersed chitosan artemether sol, and dried at 80° C. to obtain nano-chitosan artemether powder.

Embodiment 3

[0045] Take 1g of nano-chitosan and dissolve it in 100mL of water to prepare a 1% nano-chitosan sol. Take 5ml of the nano-chitosan sol, add 2.5mg of povidone K30, stir well, adjust the temperature to 60°C, add 47.5mg of artemisinin, and stir at 900r / min for 2h to obtain evenly dispersed nano-chitosan Sugar artemisinin sol was dried at 80°C to obtain nano-chitosan artemisinin complex powder.

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Abstract

The invention discloses a nanometer chitosan artemisinin compound that comprises, based on weight percentage, the following components: 40%-80% artemisinin or artemisinin derivatives; 1%-5% of polyvinyl pyrrolidone, and 15%-50% of nanometer chitosan. The nanometer chitosan artemisinin compound prepared by the invention is water-soluble artemisinin with good solubility, and can be easily absorbed by human body with no toxic and side effect; the nanostructured of which has slow release effect; the medicament half life is substantially improved; the feeding frequency is reduced; the patient compliance is increased; the drug resistance is prevented from forming; the biology utilization rate of artemisinin and derivatives are raised; and the treatment effect is increased.

Description

technical field [0001] The invention relates to a nano-medicine preparation, in particular to a nano-chitosan artemisinin complex and a preparation method thereof. Background technique [0002] Artemisinin is an effective antimalarial monomer isolated from the traditional Chinese medicine Artemisia annua, and a semiterpene lactone compound with a peroxy group. It has been clinically proven that artemisinin has an outstanding curative effect on malaria with "high efficiency, quick effect and low toxicity". The derivatives of artemisinin mainly include dihydroartemisinin, artesunate and artemether, all of which have good antimalarial activity. Artemether is listed by the World Health Organization as the drug of choice for the treatment of dangerous malaria, and it is my country's first internationally recognized innovative drug. In recent years, it has been found that artemisinin compounds have a therapeutic effect on the treatment and prevention of schistosomiasis; the late...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K31/357A61K47/48A61K47/36A61P33/06A61P33/12A61P31/04A61P37/02A61P31/20A61P1/16A61P35/00A61P29/00A61P19/02
Inventor 曾娅莉王利民钟国清何平
Owner 四川绵阳四〇四医院
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