Applications of phosphate esterified longan pulp polysaccharide in pharmacy
A longan meat polysaccharide and phosphate technology, which can be used in drug combinations, anti-toxins, allergic diseases, etc., and can solve the problems of research affecting activity and the lack of types of phosphated polysaccharides.
Inactive Publication Date: 2015-07-15
GUANGXI MEDICAL UNIVERSITY
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Problems solved by technology
There are not many types of phosphorylated polysaccharides isolated in nature, and most of them are isolated from microorganisms such as cocci, bacilli and yeasts. The limited phosphorylated polysaccharides affect people's understanding of their activity. Research
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[0014] The technical solution of the present invention will be further described below through examples.
[0015] 1. Acute toxicity test
[0016] Experimental animals: 20 Kunming mice, SPF grade, male and female, weighing 18-22 g. After fasting and drinking for 12 hours, they were randomly divided into 5 groups according to body weight (blank control group, 5mg / kg dosage group, 50mg / kg dosage group, 500mg / kg dosage group, 5000mg / kg dosage group), 4 rats in each group (male and female) Half). The mice in each test drug group were administered by intragastric administration, and the administration volume was 10ml / kg. The blank control group was intragastrically administered with double distilled water, once a day. Focus on observation within 4 hours of administration, multiple observations within 24 hours, and then regularly observe twice a day for 7 consecutive days. The results showed that compared with the blank control group, the mice in each dose group had no obvious abn...
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The invention relates to applications of phosphate esterified longan pulp polysaccharide in pharmacy, and particularly relates to application in preparation of an immunomodulatory drug or an anti-oxidative drug, wherein the applications of the phosphate esterified longan pulp polysaccharide in preparation of the immunomodulatory drug relate to the following four aspects: application in preparation of a drug for enhancing the phagocytic ability of macrophage, application in preparation of a drug for enhancing the multiplication capacity of B leukomonocyte, application in preparation of a drug for enhancing the multiplication capacity of T leukomonocyte, and application in preparation of a drug for improving the IFN-gamma level in blood serum. According to the invention, the synthetic phosphate esterified longan pulp polysaccharide is applied to an active experiment on mice; an experiment result about the immune regulation effect and the antioxidant effect of the phosphate esterified longan pulp polysaccharide is obtained, thereby providing scientific evidences for application of the phosphate esterified longan pulp polysaccharide in the field of medicine.
Description
technical field [0001] The invention relates to the application of phosphorylated longan meat polysaccharide in pharmacy. Background technique [0002] Polysaccharide is a natural immunoregulatory drug with less toxic side effects and obvious efficacy. Scientists have found that bioactive polysaccharides have significant curative effects on cancer, immune disorders, diabetes, liver damage, etc., such as the application of lentinan injection in anti-tumor treatment , the application of longan meat polysaccharide oral liquid in immune regulation, licorice polysaccharide capsule has become a new drug for the treatment of recurrent respiratory tract infection, and the application of astragalus polysaccharide injection in antiviral and so on. There are not many types of phosphorylated polysaccharides isolated in nature, and most of them are isolated from microorganisms such as cocci, bacilli and yeasts. The limited phosphorylated polysaccharides affect people's understanding of t...
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IPC IPC(8): A61K31/715A61P37/02A61P39/06
Inventor 李雪华何舟宁苑灵蒋洁蒙法艳黄燕军李福森吴妮妮林娟娟
Owner GUANGXI MEDICAL UNIVERSITY