Method for preparing high-water-solubility cydiodine with low cost

Abstract

The invention discloses a method for preparing high-water-solubility cydiodine with a low cost. The method comprises the following steps of: preparing beta-cyclodextrin into an unsaturated solution; dissolving iodine and potassium iodide into an ethanol solution to obtain an iodine solution, wherein the temperature of the iodine solution is not higher than the temperature of the beta-cyclodextrin solution, and the volume of the ethanol solution is not greater than the 30% of the volume of the beta-cyclodextrin solution; slowly adding the iodine solution into the beta-cyclodextrin solution under stirring condition, and naturally cooling to the room temperature under continuous stirring condition; carrying out natural precipitation or centrifugation on the cooled peridium suspension so as to obtain a coating; drying the peridium to be powder at the room temperature or under a low-temperature condition; then putting the cydiodine into a vacuum dry container, and vacuuming, drying and uniformly mixing at 100-200 DEG C so as to obtain the high-water-solubility cydiodine; and at the same time recycling iodine steam. The effective iodine content of the cydiodine prepared by using the method is greater than 16%, the solubility of the cydiodine in 100ml of water at 20 DEG C is greater than 0.2g, the product yield is greater than 95%, and the iodine recycling rate is greater than 99%.

Description

technical field

[0001] The invention relates to a low-cost preparation method of highly water-soluble cedi iodine, which belongs to the technical field of pharmacy. Background technique

[0002] As a low-cost coating preparation of iodine, cediiodine has the characteristics of high iodine content, good stability and low cost, and has been developed in clinical medicine for more than 20 years. At the same time, iodine disinfectant is one of the species with the greatest consumption and unique disinfection effect. It is the dream of many scientific researchers whether to develop low-cost cedi iodine into disinfectant products. However, cediodine itself is a poorly water-soluble substance, so the product has not been successfully developed into a disinfectant for many years.

[0003] There are many patents about cediodine at home and abroad, but the prepared cediodine is all non-water-soluble products. Only the invention patent "Preparation Method of Highly Water-Soluble Cedi...