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Applications of araliae cordatae total-coumarins on antimetabolic syndrome and extraction method thereof

A technology of total coumarin and extraction method, which is applied in the field of anti-metabolic syndrome application and extraction of total coumarin of celery, can solve the problems of unreported pharmacological activity, and achieve environmental friendliness, high yield and low cost. low effect

Inactive Publication Date: 2014-12-10
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are very few studies on the chemical constituents of old celery, and there is no report on its pharmacological activity.

Method used

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  • Applications of araliae cordatae total-coumarins on antimetabolic syndrome and extraction method thereof
  • Applications of araliae cordatae total-coumarins on antimetabolic syndrome and extraction method thereof
  • Applications of araliae cordatae total-coumarins on antimetabolic syndrome and extraction method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The extraction method of the total coumarin of celery comprises the following steps:

[0028] 1) Cut the dried root of old celery into small pieces of 1-2 cm, cold-soak in methanol for 48 hours according to the solid-liquid ratio of 1 g: 3-5 ml, then reflux extraction at 60 ° C for 3 times, each time for 3 hours, and combine the extractions After the solution, the solvent is recovered under reduced pressure to obtain the total extract of celery extract;

[0029] 2) After adding water to disperse the extract of the old celery extract, extract it with chloroform until the extract is colorless, corresponding to the chloroform part and the water part;

[0030] 3) The chloroform part was concentrated and then dried to obtain the total coumarin of celery.

[0031] The identification method of the total coumarin of old celery:

[0032] 1. TLC

[0033] Take a little of the prepared chloroform and dissolve it in chloroform, spot on a silica gel thin-layer plate, the thin-laye...

Embodiment 2

[0037] The preparation method of the total coumarin of old celery comprises the following steps:

[0038] 1) Cut the dried root of old celery into small pieces of 1-2cm, cold-soak with 75% ethanol solution for 48 hours according to the ratio of solid to liquid of 1g:3-5ml, then reflux extraction at 75°C for 3 times, each time for 3 hours , after merging the extracts, the solvent is recovered under reduced pressure to obtain the total extract of Chinese celery;

[0039] 2) After adding water to disperse the extract of the old celery extract, extract it with ethyl acetate until the extract is colorless, and obtain the ethyl acetate part and the water part accordingly;

[0040] 3) The ethyl acetate part was concentrated and then dried to obtain the total coumarin of celery.

[0041] According to the identification method provided in Example 1, it is proved that the ethyl acetate part is the total coumarin of celery.

Embodiment 3

[0043] The preparation method of the total coumarin of old celery comprises the following steps:

[0044] 1) Cut the dried root of celery into small pieces of 1-2cm, soak in water for 24-48 hours according to the solid-liquid ratio of 1g:3-5ml, and then reflux extraction at 100°C for 3 times, 3 hours each time, and combine the extractions After the solution, concentrate under reduced pressure to a certain concentration to obtain the concentrated solution of the total extract of celery;

[0045] 2) extract the concentrated solution of the total extract of celery with ethyl acetate until the extract is colorless, and correspondingly obtain the ethyl acetate part and the water part;

[0046] 3) The ethyl acetate part was concentrated and then dried to obtain the total coumarin of celery.

[0047] According to the identification method provided in Example 1, it is proved that the ethyl acetate part is the total coumarin of celery.

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Abstract

The invention discloses applications of araliae cordatae total-coumarins on antimetabolic syndrome and an extraction method thereof, belonging to a natural product chemical field. The extraction method of araliae cordatae total-coumarins comprises: (1) continuously back-flowing extracting herb residues after acold-soaking and extracting araliae cordatae dried roots with an alcoholic solution or water, and then obtaining a concentrate of total araliae cordatae extract or total araliae cordatae extract concentrate after pressure-reduction condensation of the extract; (2) dispersing the total araliae cordatae extract with water, extracting the liquid with chloroform or ethyl acetate until the extract liquid has no color, thereby obtaining an organic phase portion and a water phase portion; or extracting the total araliae cordatae extract concentrate with chloroform or ethyl acetate until the extract liquid has no color, thereby obtaining an organic phase portion and a water phase portion; and (3) drying after condensation of the obtained organic phase portion, to obtain the araliae cordatae total-coumarins. The araliae cordatae total-coumarins have antidiabetic, anti-hypertension, hypolipemic and anti-obesity functions. Thereby the araliae cordatae total-coumarins can be used for preparing antimetabolic syndrome medicine and / or health products.

Description

technical field [0001] The invention belongs to the field of natural product chemistry, and in particular relates to an application of total coumarin from celery to resist metabolic syndrome and an extraction method thereof. Background technique [0002] The advancement of science and technology and the improvement of living standards have greatly changed people's lifestyles. Recent studies have found that diseases that seriously threaten human health and life caused by unhealthy lifestyles and environmental factors are becoming more and more serious. These diseases are collectively referred to as "lifestyle-related diseases", mainly including hypertension, hyperlipidemia, hyperglycemia, etc. disease and obesity. Existing chemical drugs for these diseases all have disadvantages such as high toxicity and side effects, while natural herbal medicines are widely distributed, have little toxicity and side effects, are low in price, and especially have good curative effects on va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A23L1/29A61P3/00A61P3/10A61P3/04A61P9/12A61P3/06A23L33/00
Inventor 张海龙高阳杨敏飞
Owner XI AN JIAOTONG UNIV