Hydrogen-containing eye drops and preparation method and application thereof

A technology for eye drops and uses, applied in the field of medicine, can solve problems such as lack of drug treatment

Inactive Publication Date: 2013-12-04
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For a long time, people have been working on the pathogenesis and prevention measures of corneal neovascularization. Although there are many treatment methods, there

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  • Hydrogen-containing eye drops and preparation method and application thereof
  • Hydrogen-containing eye drops and preparation method and application thereof

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preparation example Construction

[0014] The embodiment of the present invention also provides a method for preparing hydrogen-containing eye drops, comprising:

[0015] Under airtight conditions, input hydrogen into the water for injection;

[0016] After the solubility of the hydrogen in the water for injection reaches saturation, stop inputting the hydrogen to obtain a hydrogen-containing solution;

[0017] Potting to obtain hydrogen-containing eye drops.

[0018] The embodiment of the present invention also provides the use of the above-mentioned hydrogen-containing eye drops for the treatment of corneal neovascularization.

[0019] Hydrogen-containing eye drops reduce the expression of vascular endothelial growth factor (VEGF), an important factor in corneal neovascularization, by reducing the inflammatory response factors interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) Decrease, and can inhibit the secretion of matrix metalloproteinases (MMPs), thereby reducing the formation of corneal neovasc...

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Abstract

The invention discloses hydrogen-containing eye drops and a preparation method and application thereof. The hydrogen-containing eye drops comprise injection water and 0.5-1.3 mmol/l hydrogen. The preparation method of the hydrogen-containing eye drops includes: introducing hydrogen into the injection water in the tightness condition; after the hydrogen is dissolved and saturate in the injection water, stopping hydrogen introduction to obtain hydrogen-containing solution; filling and sealing to obtain the hydrogen-containing eye drops. The hydrogen-containing eye drops are applied to treating corneal neovascularization. The hydrogen-containing eye drops have the advantages that expression of an important VEGF (vascular endothelial growth factor) in corneal neovascularization growth factors is decreased by lowering inflammatory response factor interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha); secretion of MMPs (matrix metalloproteinases) can be inhibited, and accordingly less corneal neovascularization occurs, keratitis response is lessened, and great benefit is brought to patients with corneal neovascularization.

Description

technical field [0001] The invention relates to the field of medicine, in particular to hydrogen-containing eye drops and a preparation method and use thereof. Background technique [0002] Transparent, avascular are important features of the cornea. Under pathological conditions such as infection, trauma, and immune response, capillaries grow from the limbus into the cornea to form corneal neovascularization. For a long time, people have been working on the pathogenesis and prevention of corneal neovascularization. Although there are many treatment methods, there is still a lack of a very safe and effective drug treatment. Therefore, the development of new and effective corneal neovascularization drugs is of great significance. Contents of the invention [0003] The object of the present invention is to provide hydrogen-containing eye drops and its preparation method and application, to solve the above-mentioned problems. [0004] An embodiment of the present invention ...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/08A61P27/02
Inventor 游玉霞王宁利赵秀丽马科王淑民
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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