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Cascaded container and method for pre-polarizing magnetic resonance contrast agent

A magnetic resonance contrast agent and container technology, which is applied in the field of laser prepolarization magnetic resonance contrast agent, can solve the problems of alkali metal temperature drop, reduce the working life of optical pumping containers, and troublesome periodic maintenance, and achieve the effect of improving efficiency

Active Publication Date: 2013-12-11
武汉中科极化医疗科技有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] 1) The working gas at room temperature (for example: Xe+He+N2 mixed gas) flows into the optical pumping container, which reduces the temperature of the optical pumping container, which leads to a drop in the temperature of the alkali metal and affects the working density of the alkali metal atom vapor;
[0005] 2) After the working gas at high pressure (for example: 5atm) flows into the optical pumping container, eddy currents will be generated, which makes the distribution of the working gas in the optical pumping container not so uniform;
[0008] 5) If the working gas is not pre-treated, it will contain a small amount of impurities such as water and oxygen. There is a potential danger of contamination of the alkali metal in the optical pumping container, such as oxidation, and usually the oxide will block the optical pumping The inlet or outlet of the container, resulting in reduced efficiency of laser prepolarized magnetic resonance contrast agents or reduced working life of optically pumped containers, making it necessary to frequently fill new alkali metals or replace new containers
However, for specific implementation and popularization and application, periodic maintenance of nearly 1000 mm long spiral prepolarization device components - cleaning the inner wall of the spiral tube, loading alkali metal Rb, etc. are extremely troublesome things
[0016] Obviously, these methods and techniques still have some shortcomings

Method used

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  • Cascaded container and method for pre-polarizing magnetic resonance contrast agent
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  • Cascaded container and method for pre-polarizing magnetic resonance contrast agent

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Embodiment Construction

[0065] Attached below figure 1 , 2 , 3 further detailed description of the technical solution of the present invention.

[0066] At first take typical cascade double container as example, describe the material, shape and the structure of each part of device of the present invention:

[0067] a) the device of the present invention ( figure 1 )——A kind of cascade container is mainly composed of an inlet pipeline 1; a first vacuum valve 2; an insulation box 3; a first porous pipeline 4; a first alkali metal filling pipeline 5; a second vacuum valve 6; ; The first platinum resistor 8; the first alkali metal 9; connecting column 10; the first light window 11; the second container 12; ; The second alkali metal 17; The second alkali metal is filled into the pipeline 18; The fourth vacuum valve 19; The second light window 20; Communication pipeline 21; The detailed description of each component is as follows:

[0068] b) Inlet pipe 1, high borosilicate glass material (note: the s...

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Abstract

The invention discloses a cascaded container for pre-polarizing a magnetic resonance contrast agent. The cascaded container comprises a heat preserving box, a first container and a second container, wherein the first container and the second container are arranged in the heat preserving box; porous pipelines are respectively arranged outside the first container and the second container; a channel and an alkali metal filling pipeline are respectively arranged on the first container and the second container; platinum resistors are respectively arranged in the first container and the second container; a first light window and a second light window are arranged on the heat preserving box; three groups of Helmholtz coils are arranged outside the heat preserving box. The invention also discloses a method for pre-polarizing the magnetic resonance contrast agent through the cascaded container. Laser pre-polarization is realized by performing multiple kinds of pretreatment on the magnetic resonance contrast agent through the cascaded container. The cascaded container is compact and simple in structure, easy to replace and convenient to use; meanwhile, the power and the contour of a laser can be fully utilized, so that the laser pumping efficiency of pre-polarization of the magnetic resonance contrast agent is effectively improved.

Description

technical field [0001] The present invention relates to the field of polarization of atoms and nuclei, and more specifically to a prepolarization method based on the premixing of flowing working gas and alkali metal atom vapor, increasing the interaction between laser and alkali metal atoms and the spin exchange collision transfer region, and provides a Cascaded containers for prepolarization, particularly suitable for laser prepolarization of magnetic resonance contrast agents. Background technique [0002] Prepolarize MR contrast agents using optically pumped spin-exchange techniques (e.g. 3 He, 129 Xe) is a very effective method, which can improve the detection sensitivity of contrast agents by ∼100,000 times, and they may become a new tool for visualizing lung and brain functions or clinical early disease diagnosis. [0003] In laser prepolarization, the establishment of the nuclear spin polarization of the lung and brain MRI contrast agents depends on the working envi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/12A61K49/06
Inventor 孙献平周欣赵修超李海东刘买利叶朝辉
Owner 武汉中科极化医疗科技有限公司
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