Application of Lycojaponicumin A in anti-Helicobacter pylori drug
An anti-Helicobacter pylori and drug technology, applied in the application field of preparing anti-Helicobacter pylori drugs, can solve problems such as indigestion, destruction of flora in the digestive tract and the like
Inactive Publication Date: 2013-12-18
QINZHOU IND RES INST
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Problems solved by technology
The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0012] Embodiment 1: the preparation of the compound Lycojaponicumin A tablet involved in the present invention:
[0013] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0014] Embodiment 2: the preparation of the compound Lycojaponicumin A capsules involved in the present invention:
[0015] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.
[0016] The following pharmacodynamic experiments will further illustrate its drug activity.
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Abstract
An in-vitro activity experiment shows that Lycojaponicumin A has high anti-Helicobacter pylori (Hp) activity. The Lycojaponicumin A can be applied to treatment of acute gastritis, chronic gastritis, stomach diseases, duodenal ulcer and the like and preparation of drugs for treating the acute gastritis, the chronic gastritis, the stomach diseases, the duodenal ulcer and the like. The application of the Lycojaponicumin A in preparation of an anti-Helicobacter pylori drug is disclosed for the first time. Due to the fact that the skeleton type is a novel skeleton type and the high anti-Helicobacter pylori inhibitory activity of the Lycojaponicumin A is previously unimagined, the possibility that other compounds give any revelation does not exist, and the Lycojaponicumin A has outstanding substantive characteristics and meanwhile has a remarkable improvement in prevention and treatment of Helicobacter pylori infection obviously.
Description
technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to the application of Lycojaponicumin A in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of proton pump inhibitor (PPI) plus two antibiotics (choose two from clarithromycin, amoxicillin, tetracycline, metronidazole, etc.). The most important factor affecting triple therapy is considered to be the resistance of Hp to antiba...
Claims
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IPC IPC(8): A61K31/424A61P31/04A61P1/04
Inventor 江春平王泽正
Owner QINZHOU IND RES INST