Traditional Chinese medicine composite of daphne giraldii nitsche and liquorice, preparation method of composite, and application of composite in preparation of medicine treating rheumatoid arthritis

Abstract

A traditional Chinese medicine composite of daphne giraldii nitsche and liquorice is characterized in that the weight ratio of bulk drugs, namely, the weight ratio of the daphne giraldii nitsche to the liquorice ranges from 3:1 to 3:2.5, the optimized weight ratio of the daphne giraldii nitsche to the liquorice ranges from 3:1 to 3:2 or 3:1.8, and the optimal ratio of the daphne giraldii nitsche to the liquorice is 3:1.5; the concentrated water of the bulk drugs is adopted to perform decoction so as to realize the further optimization, to be specific, daphne giraldii nitsche medical material coarse powder and liquorice decoction pieces are taken, and decoction are performed for two times through adding water respectively, water with the volume 10 times as large as the volume of the daphne giraldii nitsche medical material corase powder and the liquorice decoction pieces is added for decoction for 2 hours for the first time, and water with the volume 5 times as large as the volume of the daphne giraldii nitsche medical material corase powder and the liquorice decoction pieces is added for decoction for 1 hour for the second time, and the decoction water is mixed and concentrated, so as to obtain the final product. The traditional Chinese medicine composite of the daphne giraldii nitsche and the liquorice is helpful in preventing inflammation, alleviates an AA symptom, and improves the immunologic function and a tissue structure of an AA rat; the compatibility function of the daphne giraldii nitsche and liquorice is superior to the function of the single adopted daphne giraldii nitsche, and the pesticide effect of the compatibility group with the ratio being 3:2 of the daphne giraldii nitsche to the liquorice is superior to the compatibility group with the ratio being 3:1 of the daphne giraldii nitsche to the liquorice; the capability of the traditional Chinese medicine composite for reducing the content of serum inflammation cell factors as TNF-Alpha and IL-1 Beta is likely to be one of the mechanisms for treating rheumatoid arthritis.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition of Zushima and licorice, a preparation method of the traditional Chinese medicine composition of Zushima and licorice, and the preparation of the traditional Chinese medicine composition of Zushima and licorice for treating arthritis. Applications. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic erosive arthritis. The pathological features of rheumatoid arthritis are chronic inflammation of the synovium of the joints, cell infiltration, formation of synovial pannus, and the resulting destruction of articular cartilage and bone, which ultimately leads to joint deformities. Without formal treatment, about 75% of patients become disabled within 3 years. Rheumatoid arthritis is distributed all over the world, and the prevalence in different populations is 0.18%~1.07%....

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Problems solved by technology

[0014] However, in the prior art, there is no record of using Zushima and licorice compa

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