Method for establishing diabetes-inducing model

Abstract

The invention is suitable for the field of medicine and provides a method for establishing a diabetes-inducing model. The method comprises the following steps of feeding male monkeys with high-fat feed, wherein the male monkeys account for 5 / 6 of the total quantity of experimental animals, and are 7-20 years old, and the high-fat feed comprises the following main components: 18 percent of protein, 60 percent of saccharides and 22 percent of fat; feeding male monkeys with standard feed, wherein the male monkeys account for 1 / 6 of the total quantity of the experimental animals, and are 4-10 years old, and the standard feed comprises the following main components: 18 percent of protein, 69 percent of saccharides and 3 percent of fat. According to the method for establishing the diabetes-inducing model provided by the invention, by establishing the model for inducing diabetes by long-term diet, the problems that the long-term slow process of human diabetes development cannot be really simulated very well by drug modeling, and the whole organism is changed by the fact that the long-term slow process cannot be really simulated very well can be solved, and the scientificity is stronger.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a method for establishing an induced diabetes model. Background technique [0002] At present, most of the animals used in diabetes research are rats and mice, and the modeling methods include spontaneous and chemical induction. At present, rodent models are mostly used in diabetes research, but rodents are far from human relatives and have a short lifespan. Therefore, rodents are not suitable for research on the mechanism of diabetes and its complications. In non-primate animals, whether it is spontaneous, streptozotocin (streptozotocin, STZ) compound-induced, gene mutation, or other diabetes models, animal models of type 1 and type 2 diabetes have been reported. Among all kinds of animal models, the blood glucose regularity and pathological features observed in non-human primate models are most similar to the clinical features observed in human diabetic patients. [0003] In the prior...

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Problems solved by technology

[0015] The embodiment of the present invention provides a method for establishing an induced diabetes model, aiming to solve the problems of strong toxic side effects and poor stability in drug modeling in the prior art