Epidermal growth factor complex liposome and its preparation method and application

Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses an epidermal growth factor complex lipidosome, and a preparation method and an application of the lipidosome. The epidermal growth factor complex lipidosome is prepared by the following raw materials in parts by mass: 0.1-5 parts of epidermal growth factor, 5-30 parts of yeast extract, 5-30 parts of magnolol, 5-30 parts of sea buckthron oil, 40-200 parts of hydrogenated lecithin, 10-50 parts of cholesterol, 10-50 parts of glycerol and 5-30 parts of vitamin E. The lipidosome is simple in technology, safe, nontoxic, mild in property and stable in effect, and has small skin irritation.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to an epidermal growth factor complex liposome and a preparation method and application thereof. Background technique [0002] At present, traditional cosmetics only supplement the external nutrition of the skin and cover the aging skin, and cannot prevent the aging of the skin. Moreover, the actual effect of the nutrients and active cosmetics produced by the general method is not large, because the nutrients and actives are not easy to penetrate into the deep layer of the skin. Normal skin can only absorb some small molecules and fat-soluble substances, and cannot absorb macromolecular proteins. It is more difficult to enter the cells, and the active substances are often inactivated when they are used because they are easily affected by external conditions. As a polypeptide and protein, epidermal growth factor (EGF) is sensitive to enzymes, light, pH, etc., and has the charact...

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Problems solved by technology

[0002] At present, traditional cosmetics only supplement the external nutrition of the skin and cover the aging skin, and cannot prevent the aging of the skin

Moreover, the actual effect of the nutrients and active cosmetics produced by the general method is not large, because the nutrients and actives are not easy to penetrate into the deep layer of the skin. Normal skin can only absorb some small molecules and fat-soluble substances, and cannot absorb macromolecular proteins. It is more difficult to enter the cell, and the active substance is often inactivated when it is used because it is easily affected by external conditions

As a polypeptide and protein, epidermal growth factor (EGF) is sensitive to enzymes, light, pH, etc., and has the characteristics of poor stability, easy inactivation, and low bioavailability, which greatly limits its application. In order to solve the above problems, Many cosmetics simply encapsulate epidermal growth factor in liposomes to form a single epidermal growth factor liposome for use. Although the effects of enzymes and pH values ​​are isolated and the activity of epidermal growth factor is protected to a certain extent, the use of The rate is still unsatisfactory, and the skin care and skin health effects of epidermal growth factor cannot be fully exerted

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