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Synbiotic compositions for restoration and reconstitution of gut microbiota

一种合生素、组合物的技术，应用在合生素组合物领域，能够解决高死亡率等问题

Inactive Publication Date: 2014-01-01
LAVIVO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CDs are present in small numbers in the resident normal gut microbiota, but broad-spectrum antibiotics such as clindamycin, cephalosporins, and fluoroquinolones that disrupt the resident human gut microbiota lead to gut overgrowth in toxin-producing CD, killing Dead intestinal cells in the mucosa, and cause diarrhea, which in severe cases leads to pseudomembranous colitis with high mortality

Method used

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  • Synbiotic compositions for restoration and reconstitution of gut microbiota
  • Synbiotic compositions for restoration and reconstitution of gut microbiota
  • Synbiotic compositions for restoration and reconstitution of gut microbiota

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Embodiment Construction

[0048] The present invention relates to a synbiotic composition comprising at least two probiotic strains of the genus Lactobacillus (LAB) and / or Bifidobacterium (Bif) and one or more prebiotic substances. At least one bacterial strain present in the composition should have the ability to degrade starch, and at least one prebiotic substance should be starch. The bacterial strains should have the ability to attach to the gut and inhibit toxins A and B produced by C. difficile, but not inhibit growth of each other. Furthermore, the at least one or more prebiotic substances present in the composition should enhance the growth of probiotic strains, but not gastrointestinal pathogens. The synbiotic composition of the present invention is advantageously used to colonize the intestinal mucosa of a subject to prevent, treat, alleviate symptoms of antibiotic-associated diarrhea (AAD) and / or infections caused by gastrointestinal pathogens, and prevent recurrence thereof .

[0049] In ...

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Abstract

The present invention relates to synbiotic compositions comprising probiotic bacterial strains and prebiotic substances that, when combined exhibit synergistic behavior. The synergetic compositions will stimulate the indigenous microflora to restore and reconstitute in vivo gut like conditions after antibiotic associated diarrhea (AAD), and / or other gut infections caused by gastrointestinal pathogens, and relapses thereof, as well as the prevention of said disorders.

Description

[0001] invention technical field [0002] The present invention relates to a synbiotic composition comprising a probiotic bacterial strain and a prebiotic substance which exhibit synergistic behavior when combined. The synergistic composition stimulates the restoration and re-establishment of intestinal-like conditions in vivo after antibiotic-associated diarrhea (AAD) and / or other intestinal diseases caused by gastrointestinal pathogens and their recurrence, as well as the prevention of all mentioned diseases. Background of the invention [0003] The gut microbiota (microbiota) constitutes a true "organ in vitro" that has important roles for the body's intrinsic metabolic and various immune functions. This "organ" fulfills a unique digestive function that cannot be simply performed by the gastrointestinal (GI) tract of bacteria-free animals. However, GI and microbiota form a complex metabolic cross talk between bacterial species and host. [0004] The intestinal mucosal la...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A23L1/30A61P1/00A61P1/12
CPCA61K35/745A23V2002/00A23Y2220/63A23L1/3014A23L1/308A23Y2300/29A61K36/81A23L1/09A61K35/747A23L29/30A23L33/135A23L33/21A23V2400/165A23V2400/519A23L33/125A23L5/00A61P1/00A61P1/12A61P31/04Y02A50/30A61K2300/00A23V2200/3202A23V2200/3204A23V2250/28A23V2250/612
Inventor T·瓦德斯特伦A·荣P·安巴南K·K·孔德普迪
Owner LAVIVO
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