Application of Xinnaoxin Capsules in Preparation of Antidepressants

A technology of antidepressants and capsules, applied in the field of medicine, to achieve the effects of reducing immobility time, increasing content, and increasing toxicity
CN103494946BActive Publication Date: 2016-01-06GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
Publication Date
2016-01-06

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Abstract

The invention discloses application of a Xinnaoxin capsule in preparation of an antidepressant. According to experimental studies, the Xinnaoxin capsule can substantially reduce dead time during tail suspension and forced swimming of behavioral despair model mice; according to open field experiments, spontaneous activities of the mice are not influenced while dead time is substantially decreased, which prompts that the Xinnaoxin capsule has a certain anti-depression effect. Meanwhile, the Xinnaoxin capsule can substantially inhibit activity of monoamine oxidase and increase the content of a monoamine neurotransmitter in a synaptic cleft, which proves that the Xinnaoxin capsule has the anti-depression effect. Moreover, the Xinnaoxin capsule can substantially antagonize decrease of body temperature of the mice caused by reserpine and apomorphine and increase exogenous toxicity given to NE, which reveals that the capsule has the anti-depression effect. The anti-depression effect of the capsule is realized through improvement of the level of the monoamine neurotransmitter in the synaptic cleft.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of Xinnaoxin capsules in the preparation of antidepressants. Background technique

[0002] Depression is characterized by emotional disorders, which not only affects the work, study and life of patients, hinders their social functions, but is more likely to lead to suicide and endanger the lives of patients. With the fierce competition in the society and the accelerated pace of work, the number of patients with depression will also show an upward trend [1]. According to the latest survey and statistical analysis of the World Health Organization, the global incidence of depression is about 3.1%, while the incidence in developed countries is close to 6%. % of the rate increase, has become a frequently-occurring disease, a common disease.

[0003] Depression is a group of heterogeneous diseases with different etiology and pathogenesis. Its symptoms and signs are...

Claims

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