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Double-pipeline organic polymer/biological ceramic composite bone scaffold and preparation method thereof

A technology of bioceramics and polymers, which is applied in the field of manufacturing engineering, can solve the problems of insufficient mechanical strength of porous bioceramic scaffolds, difficulty in meeting the mechanical performance requirements of bone scaffolds, and occurrence of inflammatory reactions, so as to achieve good mechanical properties, improve mechanical properties, The effect of overcoming brittleness

Inactive Publication Date: 2015-01-21
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bioceramics has good biocompatibility, biodegradability, osteoinductivity, etc., and is a commonly used biomaterial in clinical practice. However, porous bioceramic scaffolds face the problems of insufficient mechanical strength, brittleness, and poor toughness, and it is difficult to meet the needs of bone scaffolds. mechanical performance requirements
Organic polymers such as PLA are biodegradable and biocompatible, and their mechanical properties can be adjusted by controlling the synthesis conditions. They have the advantages of good mechanical properties, especially good toughness, but implantation of large organic polymers into the body is prone to Inflammation

Method used

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  • Double-pipeline organic polymer/biological ceramic composite bone scaffold and preparation method thereof
  • Double-pipeline organic polymer/biological ceramic composite bone scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) First use the 3D design software Pro / Engineer to design the CAD model of the bioceramic scaffold with disconnected primary and secondary channels (such as figure 1 ), and then use the Boolean operation to obtain the negative model of the bioceramic stent; wherein, the specific structure of the disconnected primary and secondary pipelines is: the primary pipeline only extends to the outside on one side of the bioceramic stent CAD model, and the other parts The primary pipes are hidden inside the CAD model of the ceramic stent, and the secondary pipes extend to the outside of the CAD model of the ceramic stent on each face of the CAD model of the ceramic stent; both the primary pipe and the secondary pipe are cylindrical with a diameter of 600 μm.

[0032] 2) Input the data of the negative model of the bioceramic stent into the light-curing rapid prototyping machine to make the negative resin mold of the stent, and then use the gel injection molding method to make the d...

Embodiment 2

[0037] 1) First use the 3D design software Pro / Engineer to design the CAD model of the bioceramic scaffold with disconnected primary and secondary channels (such as figure 1 ), and then use the Boolean operation to obtain the negative model of the bioceramic stent; wherein, the specific structure of the disconnected primary and secondary pipelines is: the primary pipeline only extends to the outside on one side of the bioceramic stent CAD model, and the other parts The primary pipes are hidden inside the CAD model of the ceramic stent, and the secondary pipes extend to the outside of the CAD model of the ceramic stent on each face of the CAD model of the ceramic stent; both the primary pipe and the secondary pipe are cylindrical with a diameter of 400 μm.

[0038] 2) Input the data of the negative model of the bioceramic stent into the light-curing rapid prototyping machine to make the negative resin mold of the stent, and then use the gel injection molding method to make the d...

Embodiment 3

[0043] 1) First use the 3D design software Pro / Engineer to design the CAD model of the bioceramic scaffold with disconnected primary and secondary channels (such as figure 1 ), and then use the Boolean operation to obtain the negative model of the bioceramic stent; wherein, the specific structure of the disconnected primary and secondary pipelines is: the primary pipeline only extends to the outside on one side of the bioceramic stent CAD model, and the other parts The primary pipes are hidden inside the CAD model of the ceramic stent, and the secondary pipes extend to the outside of the CAD model of the ceramic stent on each face of the CAD model of the ceramic stent; both the primary pipe and the secondary pipe are cylindrical with a diameter of 800 μm.

[0044] 2) Input the data of the negative model of the bioceramic stent into the light-curing rapid prototyping machine to make the negative resin mold of the stent, and then use the gel injection molding method to make the d...

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Abstract

The invention provides a double-pipeline organic polymer / biological ceramic composite bone scaffold and a preparation method thereof. The preparation method comprises the following steps: preparing a negative model of a biological ceramic scaffold; inputting data of the negative model of the biological ceramic scaffold into a stereolithography apparatus to prepare a negative resin die for the scaffold and preparing a double-pipeline biological ceramic scaffold by using a gelcasting method; fusing a high-molecular organic polymer; filling the fused high-molecular organic polymer into a secondary pipeline so as to obtain a high-molecular organic polymer-filled scaffold; and carrying out cutting so as to obtain the double-pipeline organic polymer / biological ceramic composite bone scaffold. According to the invention, the characteristics of good toughness and adjustable mechanical properties of the organic polymer are utilized, and the organic polymer is infused into the biological ceramic scaffold so as to prepare the double-pipeline organic polymer / biological ceramic composite bone scaffold, wherein a primary pipeline is used for cell adhesion, tissue ingrowth and metabolism of nutrients, and the secondary pipeline is filled with the organic polymer, thereby exerting an effect on improvement of the mechanical properties of the scaffold.

Description

technical field [0001] The invention belongs to the field of manufacturing engineering, and in particular relates to a dual-pipe organic polymer / bioceramic composite bone support and a preparation method thereof. Background technique [0002] Bone defects caused by trauma, infection and tumors are often encountered in orthopedic clinical work. Bone tissue engineering provides a new idea for the repair of bone defects. Bioceramics has good biocompatibility, biodegradability, osteoinductivity, etc., and is a commonly used biomaterial in clinical practice. However, porous bioceramic scaffolds face the problems of insufficient mechanical strength, brittleness, and poor toughness, and it is difficult to meet the needs of bone scaffolds. mechanical performance requirements. Organic polymers such as PLA are biodegradable and biocompatible, and their mechanical properties can be adjusted by controlling the synthesis conditions. They have the advantages of good mechanical properties...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42
Inventor 连芩李涤尘李常海庄佩贺健康靳忠民王玲刘亚雄
Owner XI AN JIAOTONG UNIV