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Dogwood suspension and application of extract of dogwood suspension to preparation of medicament for treating depression

A technology of dogwood and suspension, which is applied in the field of medicine and can solve problems such as blurred vision

Inactive Publication Date: 2014-01-15
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently used to treat depression mainly include tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors, but all have varying degrees of side effects, such as drowsiness, blurred vision, high blood pressure, convulsions, and libido Low, etc., there is no therapeutic drug with good curative effect and no side effects in clinical practice
However, there is no public report about the application of Cornus officinalis suspension and extract in the preparation of drugs for the treatment of depression

Method used

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  • Dogwood suspension and application of extract of dogwood suspension to preparation of medicament for treating depression

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Effect test

Embodiment 1

[0009] The preparation of the suspension of Cornus officinalis of the present invention is carried out by using coarse powder of decoction pieces of Cornus officinalis and adding water to make a suspension, so that the suspension is equivalent to containing 1 g / mL of Cornus officinalis on the basis of crude drug.

Embodiment 2

[0011] Cornus officinalis extract of the present invention can be realized in the following ways in specific implementation:

[0012] Cornus officinalis water extract: use cornus officinalis coarse powder, add 10mL of water (W / V=1:10) to every 1g of cornus officinale according to mass volume ratio, reflux extraction 3 times, each time 2h, filter, combine filtrate, recover Water, so that the concentration of the extract is based on crude drugs, and the concentration of Cornus officinalis is 1g / mL;

[0013] Cornus officinalis 50% ethanol extract: Use cornel officinale powder, add 10mL of 50% ethanol (W / V=1︰10) to every 1g of cornel powder, reflux extraction 3 times, each time for 2h, filter , combine the filtrates, recover the ethanol until there is no alcohol smell, and make the concentration of the extract in terms of crude drugs, which is equivalent to 1g / mL containing Cornus officinalis.

[0014] Cornus officinalis 70% ethanol extract: use cornel officinale powder, add 10mL...

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Abstract

The invention relates to a dogwood suspension and application of an extract of the dogwood suspension to preparation of a medicament for treating depression and can effectively solve the problem of a medicament for preventing and treating depression. The invention adopts the technical scheme that dogwood is ground, and is added with water to form the suspension; the suspension has crude drug concentration of 1g / mL; or dogwood is ground, and is subjected to reflux extraction by one of water, ethanol, acetone, ethyl acetate and gasoline or petroleum ether to obtain a dogwood water extract, a dogwood ethanol extract, a dogwood acetone extract, a dogwood ethyl acetate extract and a dogwood gasoline or a petroleum ether extract. The dogwood suspension has simple and feasible preparation conditions, is rich in raw material sources, can be used for preparing the safety high-efficiency anti-depression medicament, develops new medicinal values of dogwood, and makes a creative contribution to development of traditional Chinese medicine and pharmacy.

Description

1. Technical field [0001] The invention relates to the field of medicine, in particular to the application of cornus officinalis suspension and extract in the preparation of drugs for treating depression. 2. Background technology [0002] Depression is an affective mental disorder caused by a variety of reasons, with persistent low mood as the main clinical manifestation, often accompanied by serious suicidal tendencies, which has caused great harm to the patient's physical and mental health, family and society. damage. According to WHO statistics, the global incidence of depression is about 11%. Depression has become the fourth largest disease in the world. It is estimated that by 2020 it may become the second largest human disease after heart disease. Depression will become The main killer of human beings in the 21st century. The drugs currently used to treat depression mainly include tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/40A61K9/10A61P25/24
Inventor 王君明张月月崔瑛
Owner HENAN UNIV OF CHINESE MEDICINE
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