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Method for preparing benzpyrole-3-formaldehyde

A technology of indole and formaldehyde, which is applied in the field of preparation of indole-3-formaldehyde, can solve the problems of low product purity and low reaction yield, and achieve the effects of simple operation, low cost and less pollution

Inactive Publication Date: 2014-01-29
纪兴国
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  • Description
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  • Application Information

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Problems solved by technology

The synthesis method of indole-3-carbaldehyde in the prior art has the defects of low reaction yield and low product purity

Method used

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  • Method for preparing benzpyrole-3-formaldehyde

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Embodiment Construction

[0014] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0015] A kind of preparation method of indole-3-carboxaldehyde, comprises the following steps (as figure 1 shown):

[0016] Step (1), the DMF of 2.5 weight parts is joined in the reactor, stirs;

[0017] In step (2), the reactor is cooled to 0°C, and 1.5 parts by weight of POCl is added dropwise. 3 And control the temperature at 0°C-10°C;

[0018] Step (3), the POCl 3 After the dropwise addition, stir for 30 min at 0°C-10°C, then add 1 part by weight of indole, raise the temperature to 35°C, a...

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Abstract

The invention discloses a method for preparing benzpyrole-3-formaldehyde. The preparation method comprises the following steps: (1) adding dimethyl formamide (DMF) to a reaction kettle, and stirring; (2) cooling the reaction kettle to 0 DEG C, dropwise adding POC13 and controlling the temperature to 0-10 DEG C; (3) stirring for 30 minutes under the condition of 0-10 DEG C after dropwise adding the POC13, then adding benzpyrole, heating to 35 DEG C to stir for 2 hours; (4) slowly adding a reaction solution in the step (3) to ice water, and stirring to clear; (5) preparing NaOH into 25% (w / v) solution, dropwise adding the NaOH solution, controlling the temperature to be less than or equal to 30 DEG C until solid is separated out, filtering, washing and drying. The method is simple to operate, low in cost, less in pollution, high in product purity, and applicable to large-scale industrial application.

Description

technical field [0001] The invention relates to a preparation method of formaldehyde derivatives, in particular to a preparation method of indole-3-carboxaldehyde. Background technique [0002] Indole-3-carboxaldehyde is a kind of pharmaceutical intermediate. At present, many manufacturers at home and abroad are using it as a raw material for the development of raw materials, and it has a good market prospect. The synthesis method of indole-3-carboxaldehyde in the prior art has the defects of low reaction yield and low product purity. Contents of the invention [0003] Aiming at the shortcomings and deficiencies of the prior art, the invention provides a method for preparing indole-3-carboxaldehyde. The invention has simple operation, low cost and less pollution, and is suitable for large-scale industrial application. [0004] The present invention is realized through the following technical solutions: [0005] A preparation method of indole-3-carboxaldehyde, comprising ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/12
CPCC07D209/12
Inventor 纪兴国
Owner 纪兴国