Mouse myopia model, and inducing device and inducing method thereof

Abstract

The invention discloses a mouse myopia model, and an inducing device and an inducing method thereof. The inducing device is formed by a screw suite and a myopia headstock, the screw suite comprises a screw, a gasket and a nut and is sutured at the top of the head of a mouse to serve as a first supporting point to fix the myopia headstock, the myopia headstock has plasticity and is formed by a kidney hole, a connecting rod, a lens frame and a nose pad, the kidney hole is used for being fixed with the screw and slight adjustment of horizontal distance, the lens frame is used for fixing a lens and can be adjusted according to the eyeball position of the mouse, the nose pad is fixed on the nose to serve as a second supporting point to reinforce the myopia headstock, and the connecting rod connects the kidney hole, the lens frame and the nose pad. Compared with the prior art, the inducing device has the advantages that the inducing device is small in operative wound, high in overall performance, stable, safe and reliable; the inducing device is of noncontact design, thereby being free of influences on physiological habits of the mouse and beneficial to repeated operation and measuring; the inducing device is easy to acquire in materials and low in cost.

Description

technical field [0001] The invention relates to a mouse myopia induction device, an induction method and a mouse myopia model in the field of myopia research. Background technique [0002] Animal models of myopia are an important part of myopia research and play a vital role in exploring the pathogenesis of myopia and seeking preventive measures. Since the establishment of the chicken myopia model in the early 1970s, a variety of model organisms have established myopia models, including rhesus monkeys, guinea pigs, mice, and zebrafish. Among them, mice have become widely used as modeling objects at home and abroad in the past 10 years because of their clear genetic background and the establishment of a series of mature gene knockout and transgenic models. [0003] The methods of inducing myopia in mice mainly include Form deprivation myopia (FDM) and Lens induced myopia (LIM). The form deprivation method is widely used, and the specific operation methods include the eyeli...

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the shortcoming of current mouse myopia induction method as much as possible, does not install the collar to limit the normal habit of mouse, absorbs the experience of high fixed stability of head, proposes a kind of mouse myopia induction device, induction method and small Mouse myopia model, relatively stable, safe, economical and minimally invasive

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