Non-leaching antimicrobial wound dressing
A wound dressing and anti-microbial technology, applied in non-adhesive dressings, dressings, antibacterial drugs, etc., can solve problems that affect the healing process and damage integrity
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[0100] Preparation of antimicrobial polymers
[0101] The antimicrobial alkylaminoalkyl polymers can be practically used as known to those skilled in the art by any conventional random radical polymerization, controlled radical polymerization (CRP), anionic polymerization and cationic polymerization. Prepared under reaction conditions for polymers of any molecular weight. The preparation can be carried out using a variety of polymerization techniques such as solution, emulsion, microemulsion, inverse emulsion, and / or bulk polymerization, as well as others available to those skilled in the art.
[0102] The molecular weight of polymers synthesized by free radical, anionic and cationic polymerization can be controlled by varying reaction conditions such as initiator type and concentration, monomer concentration, reaction temperature, chain transfer agent type and concentration. For antimicrobial polymers, typically high concentrations of initiators, low concentrations of monome...
Embodiment 1
[0146] Preparation of low MW pTBAEMA with narrow MW distribution by ATRP method
[0147] Add 0.1549g (0.1mmol) CuBr and 0.075g (0.02mmol) CuBr to the 50mL three-neck round bottom flask reactor 2 , 0.342g tris[2-(dimethylamino)ethyl]amine (Me 6 TREN) and 5.50 g of dimethyl sulfoxide (DMSO). The reactor contents were mixed and flushed with nitrogen for about 10 minutes. Meanwhile, 18.28 g (0.1 mol) of tert-butylaminoethyl methacrylate (tBAEMA) and 1.93 g (0.01 mol) of ethyl 2-bromoisobutyrate (EBiB) were mixed in a dropping funnel and flushed with nitrogen for 10 minutes . The contents of the dropping funnel were added to the reactor under nitrogen to start the polymerization. After polymerizing under nitrogen for about 2 hours, the reactor contents were precipitated in 300 mL of hexane and stirred overnight. Residual catalyst was removed from the bottom DMSO phase and polymer was recovered from the hexane phase by rotary evaporation. The polymer was redissolved in 10 g DM...
Embodiment 2
[0163] Preparation of high MW tBAEMA homopolymers with narrow molecular weight distribution by conventional free radical polymerization methods
[0164] 40 g of tert-butylaminoethyl methacrylate (tBAEMA) monomer (M) and 160 g of tetrahydrofuran (THF) solvent were charged into a 500 mL reactor equipped with an overhead condenser and agitator. The contents of the reactor with the overhead condenser were heated to 65°C for 1 hour with stirring and nitrogen flow. After nitrogen was bubbled in for 1 hour and the reaction temperature reached 65°C, initiator solution (I) containing 0.4 g AIBN (azobisisobutyronitrile) and 10 g THF was slowly added to the reactor over about 60 minutes. The reactor was maintained at 70°C overnight under a nitrogen blanket. The reactor contents were cooled to room temperature. 1 L of heptane was added to the final reaction product with stirring. The polymer product was removed by filtration and washed with 300 mL of fresh heptane. The product was dri...
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