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A kind of allicin medicinal composition and preparation method thereof

A composition and technology of allicin, applied in the field of medicine, can solve the problems of strong irritation and poor solubility of allicin, and achieve the effects of alleviating irritation, reducing oral discomfort and good absorption

Inactive Publication Date: 2016-01-20
XIANGYA STOMATOLOGICAL HOSPITAL CENT SOUTH UNIV
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Problems solved by technology

[0005] The invention overcomes the disadvantages of poor solubility and strong irritation of allicin, and discloses an allicin pharmaceutical composition and its preparation method in order to make allicin meet the needs of clinical application and large-scale production

Method used

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  • A kind of allicin medicinal composition and preparation method thereof
  • A kind of allicin medicinal composition and preparation method thereof
  • A kind of allicin medicinal composition and preparation method thereof

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preparation example Construction

[0055] (1) Preparation of allicin cyclodextrin inclusion compound:

[0056] a. Add 1 part of allicin to an appropriate amount of 95% ethanol, and stir continuously to dissolve it completely;

[0057] b. Mix 20 parts of clathrate materials with 2-5 times the amount of water, grind well, add the allicin ethanol solution prepared in step a, fully grind to paste, dry at low temperature, wash and dry to obtain allicin ring Dextrin inclusion complex.

[0058] (2) Preparation of Chinese medicine extract:

[0059] a. In parts by weight, according to 2 parts of Coptidis rhizome, 3 parts of Angelica dahurica, 3 parts of honeysuckle, 3 parts of Huoxiang, and 1 part of Asarum, take appropriate amount of various medicinal materials, mix and pulverize them in a pulverizer, and pass through a No. 2 sieve;

[0060] b. Take the medicinal material powder obtained in a and add 5 times the amount of water to decoct 3 times, 1 hour each time, combine the decoction, filter through filter paper, t...

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Abstract

The invention relates to an anti-dental-ulcer allicin medicinal composition and a preparation method thereof. The allicin medicinal composition is divided into two layers, which are respectively a medicine-containing adhesive layer and a waterproof protective layer, wherein an allicin cyclodextrin inclusion compound is prepared from allicin and cyclodextrin or derivative thereof in the medicine-containing adhesive layer, so that the solubility and stability of allicin can be improved; the content of allicin is 0.1-2 percent of the weight of the composition. According to the two-layer composition, solution of the medicine to the opposite side of the oral mucosa and two-way adhesion of a tablet between the gum and the oral mucosa can be reduced, and the medicine is concentrated in the affected part, so that the drug effect is improved. The allicin medicinal composition prepared by the method has the advantages of reliable quality, stable property and good curative effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an allicin pharmaceutical composition and a preparation method thereof. Background technique [0002] Allicin is the underground bulb of garlic, a plant of the genus Allium in the Liliaceae family. Pungent in taste, warm in nature, it belongs to the spleen, stomach, and lung meridians, and has the effects of detoxifying, killing insects, reducing swelling, and stopping dysentery. It has been used as folk medicine in my country for thousands of years. Allicin is the main active ingredient in the volatile oil of garlic. Modern studies believe that allicin has strong antibacterial, antiprotozoal, trichomonal, antiviral, antitumor, antioxidative, anti-aging, prevention and treatment of atherosclerosis, liver protection, etc. role, is a very promising drug, has great development value. [0003] Oral patch is a new dosage form that has been developed in recent years, and it will soo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61K31/255A61K31/105A61K47/48A61K36/718A61P1/02
Inventor 唐瞻贵刘欧胜刘斌杰王月红方小丹左军
Owner XIANGYA STOMATOLOGICAL HOSPITAL CENT SOUTH UNIV
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