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A kind of preparation method and application of Guihong Dieda pill

A technology of Guihong Dieda and Angelica, which is applied in the field of preparation of Guihong Dieda Pills, can solve the problems of large dosage, many impurities, and inconvenient taking for patients, and achieve the effect of reducing the dosage

Active Publication Date: 2015-10-28
淮安市清江浦区市场监管综合服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Guihong Dieda Pills. However, the method of making powder is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the This product is used clinically

Method used

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  • A kind of preparation method and application of Guihong Dieda pill

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Take 175g of Angelica, 175g of Fangfeng, 175g of Safflower, 175g of Zhitiananxing, 120g of Angelica dahurica, 50g of Panax notoginseng, and 100g of cucumber seeds and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, and mixed; every 100g of powder is added with 130-150g of refined honey to make a large honeyed pill, that is, the weight of each pill 5g.

Embodiment 2

[0018] Take 175g of Angelica, 175g of Fangfeng, 175g of Safflower, 175g of Zhitiananxing, 120g of Angelica dahurica, 50g of Panax notoginseng, and 100g of cucumber seeds and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, and mixed; every 100g of powder is added with 130-150g of refined honey to make a large honeyed pill, that is, the weight of each pill 5g.

Embodiment 3

[0020] Take 175g of Angelica, 175g of Fangfeng, 175g of Safflower, 175g of Zhitiananxing, 120g of Angelica dahurica, 50g of Panax notoginseng, and 100g of cucumber seeds and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, and mixed; every 100g of powder is added with 130-150g of refined honey to make a large honeyed pill, that is, the weight of each pill 5g.

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Abstract

The invention provides a preparation method of angelica sinensis and flowers carthami dieda (Chinese character) pills. The pills are prepared from the following crude drugs: 175g of angelica sinensis, 175g of radices sileris, 175g of flowers carthami, 175g of processed rhizoma arisaematis, 120g of radix angelicae, 50g of pseudo-ginseng and 100g of cucumber seeds in a supercritical extraction manner. Thus, the content is greatly improved, and the dose is reduced. The invention also provides application of the angelica sinensis and flowers carthami dieda pills in preparation of a drug for inhibiting rhabdomyosarcoma A-204 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Guihong Dieda Pills. Background technique [0002] Guihong Dieda Wan is recorded in the standard WS3-B-0244-90 of the Ministry of Health. The prescription is 175g of angelica, 175g of Fangfeng, 175g of safflower, 175g of Zhitiananxing, 120g of Angelica dahurica, 50g of Panax notoginseng, 100g of cucumber seeds, and the above seven flavors, crushed into Fine powder, sieve, and mix well; add 130-150g of refined honey for every 100g of powder to make big honeyed pills. Can promote blood circulation and remove blood stasis. For bruises, pain due to blood stasis. [0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Guihong Dieda Pills. However, the method of making powder is rough, backward, and has many impurities, which leads to excessive d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8884A61K9/20A61P35/00A61J3/06
Inventor 李强
Owner 淮安市清江浦区市场监管综合服务中心
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