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A kind of antibacterial composition, implant material and preparation method thereof

An implant material and composition technology, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as long-term prevention of unfavorable bacterial colonization, increased number of allergic patients, and unsuitable high support strength. , to achieve the effect of convenient large-scale production, good fixing effect and easy operation

Active Publication Date: 2016-02-24
TRANSEASY MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the original small-pore implant material is made into a large-pore size, such as a large-pore PP hernia patch, so that macrophages can effectively enter the pores and phagocytize microorganisms that cause infection. Implants or implant materials requiring high support strength are not suitable
As another example, some bacteriostatic materials are coated on the surface of the implant material, such as degradable chitosan, thereby preventing bacteria and yeasts from parasitic on the surface and hindering their colonization on the surface, but due to chitosan Belonging to biological extracts, it is easy to have heterogeneous proteins, so the number of patients with allergies increases. In addition, chitosan degrades quickly in the body, which is not good for long-term prevention of bacterial colonization; or, on the surface of implant materials Direct application of certain bacteriostatic agents to prevent bacterial colonization, however, these bacteriostatic agents also have a certain degree of cytotoxicity or biological toxicity, and there will be varying degrees of release while inhibiting bacteria, which may lead to bacteriostatic agent poisoning

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prepare the implant material coating with antibacterial function according to the following method:

[0037] (1) Prepare a mixed solution of thermoplastic polyurethane elastomer and antibacterial agent: dissolve thermoplastic polyurethane elastomer (TPU) with a molecular weight of 200,000 developed by themedics company in the United States in a mixed solvent of DMF and butanone (the volume of DMF and butanone The ratio is 2:1), and it is prepared into 20ml of mixed solution with a concentration of 15% (W / V), and 0.06ml of chlorhexidine acetate solution with a concentration of 10% is added to it. The content is 0.2% based on the weight of the polymer; after ultrasonication for 20 minutes, it is uniformly dispersed, and stirred at room temperature for 4 hours.

[0038] (2) Preparation of composite antibacterial coating: inject the above mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a positive electric field high-voltage power supply with a vol...

Embodiment 2

[0041] Prepare the implant material coating with antibacterial function according to the following method:

[0042] (1) Prepare a mixed solution of thermoplastic polyurethane elastomer and antibacterial agent: dissolve thermoplastic polyurethane elastomer (TPU) with a molecular weight of 50,000 in a mixed solvent of DMF and butanone (the volume ratio of DMF and butanone is 2:1 ), prepared into 20ml of a mixed solution with a concentration of 20% (W / V), and 0.04ml of a chlorhexidine acetate solution with a concentration of 10% was added to it. Calculated according to the effective antibacterial components, the weight content of the antibacterial agent is based on polymer 0.1% by weight; ultrasonically dispersed for 10 minutes, stirred at room temperature for 5 hours.

[0043] (2) Preparation of composite antibacterial coating: inject the above mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a positive electric field high-voltage power supply with a vo...

Embodiment 3

[0046] Prepare the implant material coating with antibacterial function according to the following method:

[0047] (1) Prepare a mixed solution of thermoplastic polyurethane elastomer and antibacterial agent: dissolve thermoplastic polyurethane elastomer (TPU) with a molecular weight of 500,000 in a mixed solvent of DMF and tetrahydrofuran (the volume ratio of DMF and tetrahydrofuran is 2:1), Prepare 20ml of a mixed solution with a concentration of 5% (W / V), add 0.1ml of benzalkonium chloride solution with a concentration of 10%, and calculate according to the active ingredients of antibacterial, and the weight content of the antibacterial agent is based on the weight of the polymer 1%; Ultrasonic for 20 minutes to disperse evenly, stir at room temperature for 2 hours.

[0048] (2) Preparation of composite antibacterial coating: inject the above mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a positive electric field high-voltage power supply with ...

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PUM

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Abstract

The invention discloses an antibacterial composition, an implant material coated with the antibacterial composition, and a preparation method of the implant material. The antibacterial composition comprises a thermoplastic polyurethane elastomer and an antibacterial agent. The implant material is prepared by the following steps: coating the antibacterial composition on the implant material through high-pressure electrospinning to form an antibacterial coating, so as to obtain the implant material with an antibacterial function. The antibacterial agent can be effectively fixed by the thermoplastic polyurethane elastomer in the antibacterial composition. Swelling leakage is avoided even if in an in-vivo complex environment by utilizing a hard shell structure formed by high-pressure electrospinning, the antibacterial agent can be effectively fixed, and the antibacterial agent is firmly combined with the material, cannot be released, is low in biotoxicity and has high biocompatibility. The preparation method is simple in process, easy to operate, low in cost and convenient for implementation of large-scale production.

Description

technical field [0001] The invention relates to the technical field of implant materials, in particular to an antibacterial composition, an implant material coated with the antibacterial composition and a preparation method thereof. Background technique [0002] Biomaterials and artificial organs have been increasingly used in clinical medicine. In a society where science and technology continue to advance, almost everyone has the possibility of permanently or temporarily implanting biomaterials or artificial organs in their bodies during their lifetime. Such as surgical suture materials, various invasive catheters, substitutes for various tissues and organs: artificial joints, artificial heart valves, artificial lenses, and even artificial hearts, lungs, and kidneys. The most important reason restricting the wider application of these biomaterials and artificial organs is biomaterial-centered infection (BCI). Therefore, research on the pathogenesis, clinical features, pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61L27/18A61L27/54A61P31/04
Inventor 韩志超许杉杉
Owner TRANSEASY MEDICAL TECH