Ion mobility spectrometer device with embedded faims cells

A technology of ion mobility spectrometer and equipment, which is applied in the direction of mass spectrometer, dynamic spectrometer, instrument, etc., and can solve problems such as meaninglessness

Inactive Publication Date: 2014-03-26
IMPLANT SCI
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  • Application Information

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Equation 1 is an infinite series, but at realistic fiel

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  • Ion mobility spectrometer device with embedded faims cells
  • Ion mobility spectrometer device with embedded faims cells
  • Ion mobility spectrometer device with embedded faims cells

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Embodiment Construction

[0043] The system described here uses combined technologies such as low (IMS) and high (FAIMS) field mobility technologies to provide several advantages, including low cost, no need for vacuum, and generation of 2-D spectra for enhanced detection and identification . The operation of two analytical devices can provide a system with advantageous flexibility by adapting the coupled instrument to the needs of the application. For IMS-FAIMS hardware-level flexibility, these instruments can be configured and optimized to exert different trade-offs for multiple detection scenarios for different target compound lists. In various embodiments described herein, the IMS and FAIMS devices may be orthogonal to each other, in particular the ion flow directions in the IMS and FAIMS devices are orthogonal. In other embodiments described in detail herein, the FAIMS device may be embedded within an IMS device, wherein ion flow may be coaxial along the IMS and FAIMS device.

[0044] Figure 1A...

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Abstract

A tandem instrument using a variable frequency pulsed ionization source and two separation techniques, low (IMS) and high (FAIMS) field mobility is provided. The analytical stage features a field driven FAIMS cell (1020) embedded on-axis within the IMS drift tube (1012). The FAIMS cell includes two parallel grids of approximately the same diameter as the IMS rings and can be placed anywhere along the drift tube and biased according to their location in the voltage divider ladder to create the same IMS field. The spacing between the grids constitutes the analytical gap where ions are subject, in addition to the drift field, to the asymmetric dispersive field of the FAIMS. The oscillatory motion performed during the high and low voltages of the asymmetric waveform separates the ions according to the difference in their mobilities. Using combined orthogonal techniques, such as low (IMS) and high (FAIMS) field mobility techniques, offers several advantages to ion detection and analysis techniques including low cost, no vacuum required, and the generation of 2-D spectra for enhanced detection and identification. Two analytical devices may be operated in different modes, which results in overall flexibility by adapting the hyphenated instrument to the application's requirements. With the IMS-FAIMS hardware level flexibility, the instruments may be configured and optimized to exploit different trade-offs suitable for a variety of detection scenarios of for different lists of target compounds.

Description

technical field [0001] This application relates to the field of chemical analysis, in particular to ion mobility spectrometry. Background technique [0002] In field applications, whether it is indoor or outdoor environment, chemical analysis instruments may face various complex mixtures. These mixtures can lead to instrument contamination and confusion due to the presence of molecular interferences that produce features that are identical to the chemical compound of interest or that cannot be resolved by the analytical instrument due to its limited resolution. Interferants can also reveal the presence of a compound of interest by affecting the detection limit. Therefore, multilevel analytical methods can be used to reduce interference and generate sufficient separation for definitive detection and identification. Multistage analysis can include a single separation technique such as MS n Mass spectrometry (MS) in the instrument or a combination of different separation tec...

Claims

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Application Information

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IPC IPC(8): G01N27/62H01J49/42
CPCG01N27/624H01J49/42
Inventor D·V·伊瓦辛S·鲍瑟莱克
Owner IMPLANT SCI
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